Gain in adiposity over 3 years is associated with progressive renal decline in multi-ethnic South-east Asians with type 2 diabetes.
Adiposity
Adult
Aged
Aged, 80 and over
Asia, Southeastern
Body Mass Index
Diabetes Mellitus, Type 2
/ complications
Diabetic Nephropathies
/ etiology
Disease Progression
Ethnicity
/ statistics & numerical data
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Male
Middle Aged
Obesity
/ physiopathology
Prognosis
Prospective Studies
Renal Insufficiency, Chronic
/ etiology
Risk Factors
Young Adult
2型糖尿病
body mass index
body weight
diabetic kidney disease
type 2 diabetes mellitus
visceral fat
体重
体重指数
内脏脂肪
糖尿病肾病
Journal
Journal of diabetes
ISSN: 1753-0407
Titre abrégé: J Diabetes
Pays: Australia
ID NLM: 101504326
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
28
09
2017
revised:
23
08
2018
accepted:
29
08
2018
pubmed:
5
9
2018
medline:
13
7
2019
entrez:
5
9
2018
Statut:
ppublish
Résumé
This study evaluated the association between gain in adiposity and renal decline in a large prospective multiethnic South-east Asian cohort with type 2 diabetes mellitus (T2DM). Three years after the baseline visit, 2057 T2DM subjects were recalled for reassessment. The final cohort comprised 1014 subjects and was categorized into tertiles based on changes in body weight (ΔWt), body mass index (ΔBMI), visceral fat area (ΔVFA), and BMI-adjusted VFA (ΔVFA Participants (mean [±SD] age 57 ± 11 years, 48.8% women, BMI 27.7 ± 5.4 kg/m Modest longitudinal gain in adiposity was associated with progressive renal decline in T2DM patients, suggesting that increased adiposity over time adversely affects renal outcomes. Therefore, a carefully designed weight-neutral or -loss antidiabetic treatment regimen is important when managing T2DM in the clinic. 摘要: 背景 这项研究在一个大型的多民族东南亚2型糖尿病患者队列中前瞻性地评估了肥胖与肾功能下降之间的关系。 方法 基线访视3年后, 再次召集原先的2057名2型糖尿病受试者进行重新评估。最终队列包括1014名受试者, 并且根据体重(ΔWt)、体重指数(ΔBMI)、内脏脂肪面积(ΔVFA)、以及校正BMI后的VFA(ΔVFA
Sections du résumé
BACKGROUND
BACKGROUND
This study evaluated the association between gain in adiposity and renal decline in a large prospective multiethnic South-east Asian cohort with type 2 diabetes mellitus (T2DM).
METHODS
METHODS
Three years after the baseline visit, 2057 T2DM subjects were recalled for reassessment. The final cohort comprised 1014 subjects and was categorized into tertiles based on changes in body weight (ΔWt), body mass index (ΔBMI), visceral fat area (ΔVFA), and BMI-adjusted VFA (ΔVFA
RESULTS
RESULTS
Participants (mean [±SD] age 57 ± 11 years, 48.8% women, BMI 27.7 ± 5.4 kg/m
CONCLUSIONS
CONCLUSIONS
Modest longitudinal gain in adiposity was associated with progressive renal decline in T2DM patients, suggesting that increased adiposity over time adversely affects renal outcomes. Therefore, a carefully designed weight-neutral or -loss antidiabetic treatment regimen is important when managing T2DM in the clinic.
摘要: 背景 这项研究在一个大型的多民族东南亚2型糖尿病患者队列中前瞻性地评估了肥胖与肾功能下降之间的关系。 方法 基线访视3年后, 再次召集原先的2057名2型糖尿病受试者进行重新评估。最终队列包括1014名受试者, 并且根据体重(ΔWt)、体重指数(ΔBMI)、内脏脂肪面积(ΔVFA)、以及校正BMI后的VFA(ΔVFA
Autres résumés
Type: Publisher
(chi)
摘要: 背景 这项研究在一个大型的多民族东南亚2型糖尿病患者队列中前瞻性地评估了肥胖与肾功能下降之间的关系。 方法 基线访视3年后, 再次召集原先的2057名2型糖尿病受试者进行重新评估。最终队列包括1014名受试者, 并且根据体重(ΔWt)、体重指数(ΔBMI)、内脏脂肪面积(ΔVFA)、以及校正BMI后的VFA(ΔVFA
Identifiants
pubmed: 30178527
doi: 10.1111/1753-0407.12848
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
316-325Subventions
Organisme : Singapore National Medical Research Council (NMRC)
ID : NMRC/PPG/AH(KTPH)/2011 and NMRC/CIRG/1398/2014
Informations de copyright
© 2018 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.