Non-thermal focused ultrasound induced reversible reduction of essential tremor in a rat model.
ET
Essential tremor
FUS
Focused ultrasound
Harmaline
ION
Inferior olivary nuclei
Intensity spatial peak pulse average
Isppa
Neuromodulation
Journal
Brain stimulation
ISSN: 1876-4754
Titre abrégé: Brain Stimul
Pays: United States
ID NLM: 101465726
Informations de publication
Date de publication:
Historique:
received:
05
12
2017
revised:
12
08
2018
accepted:
22
08
2018
pubmed:
6
9
2018
medline:
2
5
2019
entrez:
6
9
2018
Statut:
ppublish
Résumé
Essential tremor (ET) is one of the most common movement disorders of adults, characterized by postural and kinetic tremor. With drug treatment only partially efficient, new treatments are being developed. The goal of this study was to demonstrate the feasibility of non-thermal focused-ultrasound (FUS) to induce tremor-suppression in an ET rat model. Harmaline-induced tremor rats were treated with FUS along the inferior olivary (IO) system. EMG was recorded continuously during treatment in order to quantify FUS-induced tremor suppression. T2-weighted MRI was performed immediately following treatment and periodically thereafter. FUS treatment at an intensity of 27.2 W/cm These results demonstrate the feasibly for obtaining significant tremor reduction or tremor suppression induced by non-thermal, non-invasive, reversible focused-ultrasound.
Sections du résumé
BACKGROUND
Essential tremor (ET) is one of the most common movement disorders of adults, characterized by postural and kinetic tremor. With drug treatment only partially efficient, new treatments are being developed.
OBJECTIVES
The goal of this study was to demonstrate the feasibility of non-thermal focused-ultrasound (FUS) to induce tremor-suppression in an ET rat model.
METHODS
Harmaline-induced tremor rats were treated with FUS along the inferior olivary (IO) system. EMG was recorded continuously during treatment in order to quantify FUS-induced tremor suppression. T2-weighted MRI was performed immediately following treatment and periodically thereafter.
RESULTS
FUS treatment at an intensity of 27.2 W/cm
CONCLUSIONS
These results demonstrate the feasibly for obtaining significant tremor reduction or tremor suppression induced by non-thermal, non-invasive, reversible focused-ultrasound.
Identifiants
pubmed: 30181107
pii: S1935-861X(18)30297-3
doi: 10.1016/j.brs.2018.08.014
pii:
doi:
Substances chimiques
Harmaline
CN58I4TOET
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-8Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.