Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer.
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
18
09
2017
accepted:
10
08
2018
revised:
06
08
2018
pubmed:
6
9
2018
medline:
27
2
2019
entrez:
6
9
2018
Statut:
ppublish
Résumé
Cancer stem cells (CSCs) possess the capacity for self-renewal and the potential to differentiate into non-CSCs. The recent discoveries of dynamic equilibrium between CSCs and non-CSCs revealed the significance of acquiring CSC-like properties in non-CSCs as an important process in progression of cancer. The mechanism underlying acquisition of CSC-like properties has mainly been investigated in the context of epithelial-mesenchymal transition. Here, we demonstrate the dedifferentiation process may be an alternative mechanism in acquisition of CSC-like properties in human colorectal cancer cells. By exploring the single-cell gene expression analysis of organoids developed from CD44
Identifiants
pubmed: 30181548
doi: 10.1038/s41388-018-0480-0
pii: 10.1038/s41388-018-0480-0
doi:
Substances chimiques
Neoplasm Proteins
0
Nuclear Proteins
0
TWIST1 protein, human
0
Transforming Growth Factor beta
0
Twist-Related Protein 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
780-793Subventions
Organisme : Japan Society for the Promotion of Science (JSPS)
ID : 15K08970
Pays : International
Organisme : Japan Society for the Promotion of Science (JSPS)
ID : 16H06250
Pays : International
Organisme : Japan Society for the Promotion of Science (JSPS)
ID : 15H04859
Pays : International
Organisme : Japan Society for the Promotion of Science (JSPS)
ID : 16H06391
Pays : International
Organisme : Japan Society for the Promotion of Science (JSPS)
ID : 16H02662
Pays : International
Organisme : Ministry of Education, Culture, Sports, Science, and Technology (MEXT)
ID : 25115002
Pays : International
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : Practical Research for Innovative Cancer Control
Pays : International
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : Project for Cancer Research and Therapeutic Evolution
Pays : International
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