Exosome-like Nanovectors for Drug Delivery in Cancer.
Chemotherapy
drug delivery
exosomes
extracellular vesicles
gene therapy
nanoparticles
nanotechnology
surface modifications.
Journal
Current medicinal chemistry
ISSN: 1875-533X
Titre abrégé: Curr Med Chem
Pays: United Arab Emirates
ID NLM: 9440157
Informations de publication
Date de publication:
2019
2019
Historique:
received:
04
04
2018
revised:
20
06
2018
accepted:
04
07
2018
pubmed:
6
9
2018
medline:
18
12
2019
entrez:
6
9
2018
Statut:
ppublish
Résumé
Cancer treatment still represents a formidable challenge, despite substantial advancements in available therapies being made over the past decade. One major issue is poor therapeutic efficacy due to lack of specificity and low bioavailability. The progress of nanotechnology and the development of a variety of nanoplatforms have had a significant impact in improving the therapeutic outcome of chemotherapeutics. Nanoparticles can overcome various biological barriers and localize at tumor site, while simultaneously protecting a therapeutic cargo and increasing its circulation time. Despite this, due to their synthetic origin, nanoparticles are often detected by the immune system and preferentially sequestered by filtering organs. Exosomes have recently been investigated as suitable substitutes for the shortcomings of nanoparticles due to their biological compatibility and particularly small size (i.e., 30-150 nm). In addition, exosomes have been found to play important roles in cell communication, acting as natural carriers of biological cargoes throughout the body. This review aims to highlight the use of exosomes as drug delivery vehicles for cancer and showcases the various attempts used to exploit exosomes with a focus on the delivery of chemotherapeutics and nucleic acids.
Identifiants
pubmed: 30182846
pii: CMC-EPUB-92741
doi: 10.2174/0929867325666180831150259
pmc: PMC6395517
mid: NIHMS1001210
doi:
Substances chimiques
Antineoplastic Agents
0
Drug Carriers
0
RNA, Small Interfering
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6132-6148Subventions
Organisme : NCI NIH HHS
ID : R56 CA213859
Pays : United States
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Références
Biochem Biophys Res Commun. 2010 May 28;396(2):528-33
pubmed: 20434431
Curr Drug Targets. 2015;16(14):1582-90
pubmed: 25316273
Biotechnol Adv. 2013 Sep-Oct;31(5):543-51
pubmed: 22959595
Biomaterials. 2016 Sep;102:231-8
pubmed: 27344366
Lab Chip. 2015 Jun 7;15(11):2388-94
pubmed: 25940789
Nat Rev Drug Discov. 2013 May;12(5):347-57
pubmed: 23584393
Nat Cell Biol. 2008 Dec;10(12):1470-6
pubmed: 19011622
Int J Mol Med. 2013 Oct;32(4):763-7
pubmed: 23863927
Front Oncol. 2012 Apr 17;2:38
pubmed: 22649786
Nat Nanotechnol. 2013 Feb;8(2):137-43
pubmed: 23334168
Nanomedicine (Lond). 2017 Sep;12(17):2137-2148
pubmed: 28805111
Small. 2013 May 27;9(9-10):1722-33
pubmed: 23255523
Biomaterials. 2016 May;87:57-68
pubmed: 26901429
Curr Drug Metab. 2012 Jan;13(1):105-19
pubmed: 21892917
Am J Physiol Renal Physiol. 2007 May;292(5):F1657-61
pubmed: 17229675
J Transl Med. 2016 Oct 19;14(1):297
pubmed: 27756426
Adv Mater. 2018 Apr;30(15):e1702749
pubmed: 29512198
Sci Rep. 2016 Oct 05;6:34422
pubmed: 27703233
J Extracell Vesicles. 2014 Aug 04;3:
pubmed: 25143819
Front Immunol. 2015 Jan 19;5:692
pubmed: 25646096
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Nat Biotechnol. 2015 Sep;33(9):941-51
pubmed: 26348965
Theranostics. 2018 Jan 5;8(4):1131-1145
pubmed: 29464004
J Transl Med. 2005 Mar 02;3(1):10
pubmed: 15740633
J Transl Med. 2005 Feb 21;3(1):9
pubmed: 15723705
Clin Cancer Res. 2016 Jan 15;22(2):395-404
pubmed: 26369630
Nanoscale. 2017 Oct 5;9(38):14581-14591
pubmed: 28932838
Clin Cancer Res. 2005 Feb 1;11(3):1010-20
pubmed: 15709166
Cancer Treat Rev. 2014 Sep;40(8):909-16
pubmed: 24969326
J Extracell Vesicles. 2018 Jan 17;7(1):1422676
pubmed: 29372017
Methods. 2012 Feb;56(2):293-304
pubmed: 22285593
J Immunol Methods. 2001 Jan 1;247(1-2):163-74
pubmed: 11150547
AAPS J. 2017 Mar;19(2):475-486
pubmed: 27882487
J Vis Exp. 2012 Jan 09;(59):e3037
pubmed: 22257828
Clin Cancer Res. 2001 Feb;7(2):223-5
pubmed: 11234871
Sci Rep. 2016 Feb 25;6:21933
pubmed: 26911358
PLoS One. 2015 Mar 23;10(3):e0117495
pubmed: 25798887
Curr Drug Targets. 2015;16(13):1540-7
pubmed: 25382209
Int J Hyperthermia. 2015;31(5):498-506
pubmed: 25955015
Sci Rep. 2015 Dec 03;5:17543
pubmed: 26633001
Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):148-156
pubmed: 26928656
Mol Med Rep. 2016 Oct;14(4):3452-8
pubmed: 27513187
Nat Biotechnol. 2011 Apr;29(4):341-5
pubmed: 21423189
Gene Ther. 2002 Dec;9(24):1647-52
pubmed: 12457277
J Biol Chem. 2009 Dec 4;284(49):34211-22
pubmed: 19801663
PLoS One. 2012;7(4):e35487
pubmed: 22530032
Nat Mater. 2016 Sep;15(9):1037-46
pubmed: 27213956
J Dairy Sci. 2015 May;98(5):2920-33
pubmed: 25726110
Oncogene. 2003 Nov 24;22(53):8628-33
pubmed: 14634624
Mol Ther. 2018 Mar 7;26(3):774-783
pubmed: 29456019
Biomater Sci. 2017 Feb 28;5(3):378-387
pubmed: 28133653
Curr Rheumatol Rev. 2014;10(1):22-34
pubmed: 25229496
Trends Cell Biol. 2015 Jun;25(6):364-72
pubmed: 25683921
Adv Mater. 2017 Sep;29(33):
pubmed: 28681981
Theranostics. 2018 Jan 1;8(1):237-255
pubmed: 29290805
Mol Ther. 2013 Jul;21(7):1345-57
pubmed: 23752315
J Extracell Vesicles. 2012 Apr 16;1:
pubmed: 24009879
J Control Release. 2016 Sep 28;238:58-70
pubmed: 27448444
Semin Immunol. 2018 Feb;35:69-79
pubmed: 29289420
Nanomedicine (Lond). 2016 Jan;11(1):81-100
pubmed: 26653875
ACS Appl Mater Interfaces. 2017 Aug 23;9(33):27441-27452
pubmed: 28762264
Cell. 1987 Dec 4;51(5):813-9
pubmed: 3315233
Clin Transl Med. 2017 Dec 11;6(1):44
pubmed: 29230567
Int J Nanomedicine. 2016 Jul 04;11:3049-63
pubmed: 27445473
Gynecol Oncol. 2008 Jul;110(1):13-21
pubmed: 18589210
Annu Rev Med. 2012;63:185-98
pubmed: 21888516
Nanomedicine. 2016 Apr;12(3):655-664
pubmed: 26586551
Adv Clin Chem. 2016;74:103-41
pubmed: 27117662
ACS Nano. 2013 Sep 24;7(9):7698-710
pubmed: 24004438
Biochim Biophys Acta. 2012 Aug;1826(1):103-11
pubmed: 22503823
Biomaterials. 2017 Dec;147:155-168
pubmed: 28946131
Anal Biochem. 2012 Dec 15;431(2):96-8
pubmed: 22982508
J Control Release. 2015 Feb 10;199:145-55
pubmed: 25523519
Int J Nanomedicine. 2018 Jan 30;13:585-599
pubmed: 29430178
Curr Med Chem. 2018;25(34):4208-4223
pubmed: 28933296
J Nanosci Nanotechnol. 2017 Feb;17(2):977-82
pubmed: 29671486
Mol Med Rep. 2017 May;15(5):2925-2930
pubmed: 28358432
Acta Pharmacol Sin. 2017 Jun;38(6):754-763
pubmed: 28392567
Nat Rev Immunol. 2009 Aug;9(8):581-93
pubmed: 19498381
Biomaterials. 2014 Feb;35(7):2383-90
pubmed: 24345736
Oncotarget. 2017 Jan 17;8(3):3933-3945
pubmed: 27965469
Front Med (Lausanne). 2017 Mar 08;4:18
pubmed: 28337438
Clin Cancer Res. 2016 Jul 15;22(14):3499-512
pubmed: 26944067
Semin Immunopathol. 2011 Sep;33(5):441-54
pubmed: 21688197
Mol Cell Proteomics. 2010 Feb;9(2):197-208
pubmed: 19837982
Oncotarget. 2015 Feb 10;6(4):2366-84
pubmed: 25544774
ACS Appl Mater Interfaces. 2017 Jul 19;9(28):23441-23449
pubmed: 28640590
Mol Ther. 2008 Apr;16(4):782-90
pubmed: 18362931
J Control Release. 2015 May 10;205:35-44
pubmed: 25483424
Biotechnol Lett. 2016 Nov;38(11):1857-1866
pubmed: 27484689
Nature. 2007 Jul 5;448(7149):39-43
pubmed: 17572664
Endocrinology. 2010 Feb;151(2):458-65
pubmed: 20016026
Methods Mol Biol. 2010;588:63-6
pubmed: 20012820
Eur J Immunol. 2003 Feb;33(2):522-31
pubmed: 12645951
J Biomed Mater Res A. 2014 Oct;102(10):3540-9
pubmed: 25269799
Oncotarget. 2015 Aug 14;6(23):19514-27
pubmed: 26098775
J Exp Med. 1996 Mar 1;183(3):1161-72
pubmed: 8642258
J Control Release. 2014 Oct 28;192:262-70
pubmed: 25084218
Chem Commun (Camb). 2018 Jun 26;54(52):7219-7222
pubmed: 29900459
Proteomics Clin Appl. 2010 Jan;4(1):84-96
pubmed: 21137018
Int J Nanomedicine. 2012;7:1525-41
pubmed: 22619510
Kidney Int. 2012 Nov;82(9):1024-32
pubmed: 22785172
ACS Nano. 2017 Mar 28;11(3):3262-3273
pubmed: 28264157
Methods Mol Biol. 2011;728:235-46
pubmed: 21468952
J Proteomics. 2010 Sep 10;73(10):1907-20
pubmed: 20601276
Sci Rep. 2017 Dec 6;7(1):17095
pubmed: 29213052
Oncotarget. 2016 Aug 23;7(34):54676-54690
pubmed: 27419627
Biomaterials. 2016 Mar;82:168-77
pubmed: 26761780
Sci Rep. 2017 Aug 11;7(1):7991
pubmed: 28801676
Future Oncol. 2017 Dec;13(28):2583-2592
pubmed: 29198150
Nanomedicine (Lond). 2017 Jun;12(11):1319-1334
pubmed: 28520517
Mol Ther. 2013 Jan;21(1):185-91
pubmed: 23032975
Pharm Res. 2015 Jun;32(6):2003-14
pubmed: 25609010
Biomaterials. 2018 Jan;150:137-149
pubmed: 29040874
Colloids Surf B Biointerfaces. 2015 Dec 1;136:694-703
pubmed: 26513752
Lab Chip. 2014 Jun 7;14(11):1891-900
pubmed: 24722878
J Vet Med Sci. 2012 Nov;74(11):1523-5
pubmed: 22785357