Driving pressure and acute respiratory distress syndrome in critically ill patients.
Adult
Correlation of Data
Critical Care
/ methods
Critical Illness
/ therapy
Female
Humans
Intensive Care Units
/ statistics & numerical data
Male
Middle Aged
Positive-Pressure Respiration
/ adverse effects
Respiration, Artificial
/ adverse effects
Respiratory Distress Syndrome
/ etiology
Risk Adjustment
Risk Factors
acute respiratory distress syndrome
driving pressure
intensive care unit
mechanical ventilation
risk prediction
Journal
Respirology (Carlton, Vic.)
ISSN: 1440-1843
Titre abrégé: Respirology
Pays: Australia
ID NLM: 9616368
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
26
03
2018
revised:
04
07
2018
accepted:
09
08
2018
pubmed:
6
9
2018
medline:
21
1
2020
entrez:
6
9
2018
Statut:
ppublish
Résumé
Elevated driving pressure (ΔP) may be associated with increased risk of acute respiratory distress syndrome (ARDS) in patients admitted via the emergency department and with post-operative pulmonary complications in surgical patients. This study investigated the association of higher ΔP with the onset of ARDS in a high-risk, intensive care unit (ICU) population. This is a secondary analysis of a prospective multicentre observational study. Data for this ancillary study were obtained from intubated adult patients with at least one ARDS risk factor upon ICU admission enrolled in a previous multicentre observational study. Patients were followed up for the development of ARDS within 7 days (primary outcome). Univariate and multivariate analyses tested the association between ΔP (measured at ICU admission (baseline) or 24 h later (day 1)) and the development of ARDS. A total of 221 patients were included in this study, among whom 34 (15%) developed ARDS within 7 days. These patients had higher baseline ΔP than those who did not (mean ± SD: 12.5 ± 3.1 vs 9.8 ± 3.4 cm H Among at-risk ICU patients, higher ΔP may identify those who are more likely to develop ARDS.
Sections du résumé
BACKGROUND AND OBJECTIVE
Elevated driving pressure (ΔP) may be associated with increased risk of acute respiratory distress syndrome (ARDS) in patients admitted via the emergency department and with post-operative pulmonary complications in surgical patients. This study investigated the association of higher ΔP with the onset of ARDS in a high-risk, intensive care unit (ICU) population.
METHODS
This is a secondary analysis of a prospective multicentre observational study. Data for this ancillary study were obtained from intubated adult patients with at least one ARDS risk factor upon ICU admission enrolled in a previous multicentre observational study. Patients were followed up for the development of ARDS within 7 days (primary outcome). Univariate and multivariate analyses tested the association between ΔP (measured at ICU admission (baseline) or 24 h later (day 1)) and the development of ARDS.
RESULTS
A total of 221 patients were included in this study, among whom 34 (15%) developed ARDS within 7 days. These patients had higher baseline ΔP than those who did not (mean ± SD: 12.5 ± 3.1 vs 9.8 ± 3.4 cm H
CONCLUSION
Among at-risk ICU patients, higher ΔP may identify those who are more likely to develop ARDS.
Banques de données
ClinicalTrials.gov
['NCT02070536']
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
137-145Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2018 Asian Pacific Society of Respirology.