Bugs in the system: bringing the human microbiome to bear in cancer immunotherapy.
Microbiome
cancer immunotherapy
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
6
9
2018
medline:
8
8
2019
entrez:
6
9
2018
Statut:
ppublish
Résumé
The influence of the composition of the human microbiome on the efficacy of cancer directed immunotherapies, such as antibodies directed against the programmed cell death 1 protein (PD-1) or its ligand (PD-L1), has garnered increasing attention as the role of immunotherapies in the care of cancer has grown. Dysbiosis (altered microbiota) has recently been reported to adversely affect the efficacy of cancer directed immunotherapies, and correction of this dysbiosis has the potential to improve the efficacy of these treatments. However, the exact mechanisms underlying this relationship remains unknown. Current methods for characterizing the microbiome likely capture only a small portion of the highly complex interaction between the microbiome and the immune system. Here we discuss the recent reports of the influence of dysbiosis on cancer immunotherapy, methods to more fully characterize the interaction between the microbiome and the immune system, and methods of modulating the immune system to improve the efficacy of cancer immunotherapy.
Identifiants
pubmed: 30183502
doi: 10.1080/19490976.2018.1511665
pmc: PMC6546317
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antibodies, Monoclonal
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
109-112Subventions
Organisme : NCI NIH HHS
ID : P30 CA086862
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005605
Pays : United States
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