Clinicopathologic characteristics of non-small cell lung cancer in patients with smoking-related chronic obstructive pulmonary disease.
Adenocarcinoma
Chronic obstructive pulmonary disease
Clinical stage I
Non-small cell lung cancer
Thoracic surgery
Journal
General thoracic and cardiovascular surgery
ISSN: 1863-6713
Titre abrégé: Gen Thorac Cardiovasc Surg
Pays: Japan
ID NLM: 101303952
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
09
04
2018
accepted:
02
09
2018
pubmed:
7
9
2018
medline:
12
3
2019
entrez:
7
9
2018
Statut:
ppublish
Résumé
The purpose of this study was to clarify the clinicopathologic characteristics of non-small cell lung cancer (NSCLC) patients with smoking-related chronic obstructive pulmonary disease (COPD) and to evaluate the biological behavior of this disease. We investigated the association between smoking-related COPD, the recurrence-free proportion (RFP) and the clinicopathological features of clinical stage I NSCLC patients. Between 2005 and 2014, 218 consecutive patients with clinical stage I NSCLC underwent complete resection with lobectomy or greater and systematic lymph node dissection. Differences in categorical outcomes were evaluated by the χ The 5-year RFP of clinical stage I NSCLC patients with smoking-related COPD was 55%, which was significantly lower than in those without smoking-related COPD (85%; p < 0.001). Postoperative pathological factors, including moderate or poor histological differentiation, intratumoral vascular invasion and lymph node metastasis, were detected more often in patients with smoking-related COPD. In adenocarcinoma patients, the 5-year RFP of patients with smoking-related COPD was 47%, which was significantly lower than in those without smoking-related COPD (87%; p < 0.001). The presence of a solid component was more frequently found in patients with smoking-related COPD (p = 0.007). Clinical stage I NSCLC patients with smoking-related COPD have histologically more invasive tumors than those without smoking-related COPD.
Sections du résumé
BACKGROUND
BACKGROUND
The purpose of this study was to clarify the clinicopathologic characteristics of non-small cell lung cancer (NSCLC) patients with smoking-related chronic obstructive pulmonary disease (COPD) and to evaluate the biological behavior of this disease. We investigated the association between smoking-related COPD, the recurrence-free proportion (RFP) and the clinicopathological features of clinical stage I NSCLC patients.
METHODS
METHODS
Between 2005 and 2014, 218 consecutive patients with clinical stage I NSCLC underwent complete resection with lobectomy or greater and systematic lymph node dissection. Differences in categorical outcomes were evaluated by the χ
RESULTS
RESULTS
The 5-year RFP of clinical stage I NSCLC patients with smoking-related COPD was 55%, which was significantly lower than in those without smoking-related COPD (85%; p < 0.001). Postoperative pathological factors, including moderate or poor histological differentiation, intratumoral vascular invasion and lymph node metastasis, were detected more often in patients with smoking-related COPD. In adenocarcinoma patients, the 5-year RFP of patients with smoking-related COPD was 47%, which was significantly lower than in those without smoking-related COPD (87%; p < 0.001). The presence of a solid component was more frequently found in patients with smoking-related COPD (p = 0.007).
CONCLUSION
CONCLUSIONS
Clinical stage I NSCLC patients with smoking-related COPD have histologically more invasive tumors than those without smoking-related COPD.
Identifiants
pubmed: 30187259
doi: 10.1007/s11748-018-1007-x
pii: 10.1007/s11748-018-1007-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
239-246Références
Exp Lung Res. 2005 Jan-Feb;31(1):57-82
pubmed: 15765919
Ann Thorac Surg. 2006 May;81(5):1830-7
pubmed: 16631680
Ann Thorac Surg. 2006 Jun;81(6):1988-95
pubmed: 16731118
J Thorac Cardiovasc Surg. 2006 Oct;132(4):769-75
pubmed: 17000286
Nature. 2008 Jul 24;454(7203):436-44
pubmed: 18650914
Eur Respir J. 2009 Aug;34(2):380-6
pubmed: 19196816
J Natl Cancer Inst. 2009 Apr 15;101(8):554-9
pubmed: 19351920
Cancer. 2010 Feb 1;116(3):659-69
pubmed: 20014400
Cancer Cell. 2010 Jan 19;17(1):89-97
pubmed: 20129250
Respiration. 2011;81(4):265-84
pubmed: 21430413
Am J Respir Crit Care Med. 2013 Feb 15;187(4):347-65
pubmed: 22878278
Am J Respir Crit Care Med. 2013 Jul 15;188(2):157-66
pubmed: 23855692
J Thorac Cardiovasc Surg. 2013 Aug;146(2):372-8
pubmed: 23870323
Chest. 2014 Feb;145(2):346-353
pubmed: 24008835
Int J Oncol. 2014 Mar;44(3):874-82
pubmed: 24424784
Int J Chron Obstruct Pulmon Dis. 2014 Sep 30;9:1053-8
pubmed: 25336937
Clin Transl Med. 2015 Dec;4(1):68
pubmed: 26220864
J Thorac Oncol. 2015 Sep;10(9):1240-1242
pubmed: 26291007
J Thorac Oncol. 2016 Sep;11(9):1433-46
pubmed: 27448762
Ann Thorac Surg. 1998 Nov;66(5):1787-90
pubmed: 9875790