Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia.
Adolescent
Adult
Aged
Aged, 80 and over
DNA Copy Number Variations
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genetic Variation
Genomics
/ methods
Humans
Male
Middle Aged
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ genetics
Prognosis
Survival Analysis
Young Adult
Journal
Haematologica
ISSN: 1592-8721
Titre abrégé: Haematologica
Pays: Italy
ID NLM: 0417435
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
26
04
2018
accepted:
30
08
2018
pubmed:
8
9
2018
medline:
6
5
2020
entrez:
8
9
2018
Statut:
ppublish
Résumé
To shed light onto the molecular basis of Philadelphia chromosome-positive acute lymphoblastic leukemia and to investigate the prognostic role of additional genomic lesions, we analyzed copy number aberrations using the Cytoscan HD Array in 116 newly diagnosed adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia enrolled in four different GIMEMA protocols, all based on a chemotherapy-free induction strategy. This analysis showed that patients with Philadelphia chromosome-positive acute lymphoblastic leukemia carry an average of 7.8 lesions/case, with deletions outnumbering gains (88%
Identifiants
pubmed: 30190342
pii: haematol.2018.196055
doi: 10.3324/haematol.2018.196055
pmc: PMC6355475
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
312-318Informations de copyright
Copyright © 2019 Ferrata Storti Foundation.
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