The contributions of mesoderm-derived cells in liver development.
Cholangiocyte
Hepatic stellate cells
Hepatoblast
Hepatocyte
Liver
Septum transversum mesenchyme
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
01
03
2018
revised:
31
08
2018
accepted:
02
09
2018
pubmed:
9
9
2018
medline:
28
4
2020
entrez:
9
9
2018
Statut:
ppublish
Résumé
The liver is an indispensable organ for metabolism and drug detoxification. The liver consists of endoderm-derived hepatobiliary lineages and various mesoderm-derived cells, and interacts with the surrounding tissues and organs through the ventral mesentery. Liver development, from hepatic specification to liver maturation, requires close interactions with mesoderm-derived cells, such as mesothelial cells, hepatic stellate cells, mesenchymal cells, liver sinusoidal endothelial cells and hematopoietic cells. These cells affect liver development through precise signaling events and even direct physical contact. Through the use of new techniques, emerging studies have recently led to a deeper understanding of liver development and its related mechanisms, especially the roles of mesodermal cells in liver development. Based on these developments, the current protocols for in vitro hepatocyte-like cell induction and liver-like tissue construction have been optimized and are of great importance for the treatment of liver diseases. Here, we review the roles of mesoderm-derived cells in the processes of liver development, hepatocyte-like cell induction and liver-like tissue construction.
Identifiants
pubmed: 30193996
pii: S1084-9521(17)30532-3
doi: 10.1016/j.semcdb.2018.09.003
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
63-76Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.