Functional characterization of the GABA transporter GAT-1 from the deep-sea mussel Bathymodiolus septemdierum.

Animals Biological Transport GABA Plasma Membrane Transport Proteins / genetics Mytilidae / metabolism Oocytes / metabolism Protein Transport RNA, Messenger / genetics Substrate Specificity Xenopus laevis / genetics gamma-Aminobutyric Acid / metabolism
Bathymodiolus septemdierum GABA GAT-1 Hypotaurine

Journal

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
ISSN: 1531-4332
Titre abrégé: Comp Biochem Physiol A Mol Integr Physiol
Pays: United States
ID NLM: 9806096

Informations de publication

Date de publication:
01 2019
Historique:
received: 15 06 2018
revised: 27 08 2018
accepted: 28 08 2018
pubmed: 9 9 2018
medline: 18 12 2019
entrez: 9 9 2018
Statut: ppublish

Résumé

Mammalian γ-aminobutyric acid (GABA) transporter subtype 1 (GAT-1) is a specific transporter for GABA, an inhibitory neurotransmitter in GABA-ergic neurons. GAT-1 belongs to the GAT group, in which five related transporters, GAT-2, GAT-3, GAT-4, CT1, and TAUT are known in mammals. By contrast, the deep-sea mussel, Bathymodiolus septemdierum has only two GAT group members, BsGAT-1 and BsTAUT, and their function in environmental adaptation is of interest to better understand the physiology of deep-sea organisms. Compared with BsTAUT, the function of BsGAT-1 is unknown. Here, we report the functional characterization of BsGAT-1. Analyses of BsGAT-1 expressed in Xenopus oocytes showed that it could transport GABA in a Na

Identifiants

DOI: 10.1016/j.cbpa.2018.08.016 PMID: 30195015
pubmed: 30195015
pii: S1095-6433(18)30143-0
doi: 10.1016/j.cbpa.2018.08.016
pii:
doi:

Substances chimiques

GABA Plasma Membrane Transport Proteins 0
RNA, Messenger 0
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-7

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Azusa Kinjo (A)

Atmosphere and Ocean Research Institute, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8564, Japan. Electronic address: kinjokakumura@aori.u-tokyo.ac.jp.

Mieko Sassa (M)

Atmosphere and Ocean Research Institute, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8564, Japan; Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8563, Japan.

Tomoko Koito (T)

College of Bioresource Sciences, Nihon University, Fujisawa 252-0880, Japan.

Miwa Suzuki (M)

College of Bioresource Sciences, Nihon University, Fujisawa 252-0880, Japan.

Koji Inoue (K)

Atmosphere and Ocean Research Institute, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8564, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Functional characterization of the GABA...
questionsmedicales.fr › Métabolisme › Transport biologique › Functional characterization of the GABA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs de neurotransmetteurs › Transporteurs plasmiques de neurotransmetteurs › Transporteurs de GABA › Functional characterization of the GABA...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Mollusca › Bivalvia › Mytilidae › Functional characterization of the GABA...
questionsmedicales.fr › Cellules › Cellules germinales › Ovocytes › Functional characterization of the GABA...
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des protéines › Functional characterization of the GABA...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Functional characterization of the GABA...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Functional characterization of the GABA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Pipidae › Xenopus › Xenopus laevis › Functional characterization of the GABA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Functional characterization of the GABA...