Characterizing cancer cachexia in the geriatric oncology population.
Cachexia
Functional impairment
Geriatric assessment
Geriatric oncology
Sarcopenia
Weight loss
Journal
Journal of geriatric oncology
ISSN: 1879-4076
Titre abrégé: J Geriatr Oncol
Pays: Netherlands
ID NLM: 101534770
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
04
04
2018
revised:
31
07
2018
accepted:
10
08
2018
pubmed:
10
9
2018
medline:
23
7
2020
entrez:
10
9
2018
Statut:
ppublish
Résumé
Cancer cachexia, characterized by weight loss and sarcopenia, leads to a decline in physical function and is associated with poorer survival. Cancer cachexia remains poorly described in older adults with cancer. This study aims to characterize cancer cachexia in older adults by assessing its prevalence utilizing standard definitions and evaluating associations with components of the geriatric assessment (GA) and survival. Patients with cancer older than 65 years of age who underwent a GA and had baseline CT imaging were eligible in this cross-sectional study. Cancer cachexia was defined by the international consensus definition reported in 2011. Sarcopenia was measured using cross-sectional imaging and utilizing sex-specific cut-offs. Associations between cachexia, sarcopenia, and weight loss with survival and GA domains were explored. Mean age of 100 subjects was 79.9 years (66-95) and 65% met criteria for cancer cachexia. Cachexia was associated with impairment in instrumental activities of daily living (IADL) (p = .017); no significant association was found between sarcopenia or weight loss and IADL impairment. Cachexia was significantly associated with poorer survival (median 1.0 vs 2.1 years, p = .011). Cancer cachexia as defined by the international consensus definition is prevalent in older adults with cancer and is associated with functional impairment and decreased survival. Larger prospective studies are needed to further describe cancer cachexia in this population.
Identifiants
pubmed: 30196027
pii: S1879-4068(18)30124-3
doi: 10.1016/j.jgo.2018.08.008
pmc: PMC6401352
mid: NIHMS1504168
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
415-419Subventions
Organisme : NIA NIH HHS
ID : K24 AG056589
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177592
Pays : United States
Organisme : NCI NIH HHS
ID : R25 CA102618
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA189961
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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