Antinociceptive action of Achillea biebersteinii methanolic flower extract is mediated by interaction with cholinergic receptor in mouse pain models.
Achillea
/ chemistry
Analgesics
/ pharmacology
Animals
Disease Models, Animal
Female
Flowers
/ chemistry
Methanol
/ chemistry
Mice
Mice, Inbred BALB C
Pain
/ drug therapy
Pain Measurement
/ methods
Phytotherapy
/ methods
Plant Extracts
/ pharmacology
Plant Leaves
/ chemistry
Receptors, Cholinergic
/ metabolism
Achillea biebersteinii
Antinociceptive effect
Cholinergic receptor
GC–MS
Paw-licking test
Tail-flick test
Writhing test
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
12
05
2018
accepted:
24
08
2018
pubmed:
10
9
2018
medline:
28
11
2019
entrez:
10
9
2018
Statut:
ppublish
Résumé
Achillea biebersteinii is a perennial aromatic herb that grows in the Mediterranean area. The leaves of this plant are used in foods as bittering and appetizing agents. In folk medicine, it is used for the treatment of stomachache and abdominal pain. In this study, the analgesic effect of A. biebersteinii methanolic flower extract was tested in three pain models, namely: writhing, tail-flick and paw-licking (formalin) tests. A. biebersteinii extract inhibited abdominal cramps produced by acetic acid. The effect of A. biebersteinii was better than that of 70 mg/kg indomethacin. In tail flick, A. biebersteinii extract increased latency at 30 min and was as effective as 100 mg/kg diclofenac sodium. In formalin test, A. biebersteinii extracts decreased paw-licking and flinching response in early and late phases. Atropine blocked the action of A. biebersteinii extract (300 mg/kg) in the late phase of formalin test as well as in writhing and tail-flick tests. GC-MS analysis revealed that ascaridole and iso-ascaridole were the main constituents of A. biebersteinii flower extract. In conclusion, this study shows for the first time that the antinociceptive effect of A. biebersteinii is mediated by the cholinergic receptor.
Identifiants
pubmed: 30196468
doi: 10.1007/s10787-018-0524-7
pii: 10.1007/s10787-018-0524-7
doi:
Substances chimiques
Analgesics
0
Plant Extracts
0
Receptors, Cholinergic
0
Methanol
Y4S76JWI15
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
961-968Références
Abd-Alla HI, Shalaby NMM, Hamed MA, El-Rigal NS, Al-Ghamdi SN, Bouajila J (2016) Phytochemical composition, protective and therapeutic effect on gastric ulcer and a-amylase inhibitory activity of Achillea biebersteinii Afan. Arch Pharmacol Res 39(1):10–20
doi: 10.1007/s12272-014-0544-9
Abdel-Rahman RF, Alqasoumi SIB, El-Desoky AH, Solimand GA, Paré PW, Hegazy MEF (2015) Evaluation of the anti-inflammatory, analgesic and anti-ulcerogenic potentials of Achillea fragrantissima (Forssk.). South Afr J Bot 98:122–127
doi: 10.1016/j.sajb.2015.02.009
Abotsi WKM, Lamptey SB, Afrane S, Boakye-Gyasi E, Umoh RU, Woode E (2016) An evaluation of the anti-inflammatory, antipyretic and analgesic effects of hydroethanol leaf extract of Albizia zygia in animal models. Pharm Biol 55:338–348
doi: 10.1080/13880209.2016.1262434
Abul-Husn NS, Sutak M, Milne B, Jhamandas K (2007) Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of mu- and delta-opioid receptor antagonists. Br J Pharmacol 151(6):877–887
doi: 10.1038/sj.bjp.0707277
Afify EA, Alkreathy HM, Ali AS, Alfaifi HA, Khan LM (2017) Characterization of the antinociceptive mechanisms of khat extract (Catha edulis) in Mice. Front Neurol 8:69
doi: 10.3389/fneur.2017.00069
Ahmadi K, Wassim A, Ream N (2017) Evaluation of hypoglycemic effect of Achillea biebersteinii Afan., growing in Syria, in induced diabetic rats. Int J Pharm Phytochem Res 9(2):215–222
Akkol EK, Koca U, Pesin I, Yilmazer D (2011) Evaluation of the wound healing potential of Achillea biebersteinii Afan (Asteraceae) by in vivo excision and incision models. Evid Based Complement Altern Med. https://doi.org/10.1093/ecam/nep039
doi: 10.1093/ecam/nep039
Al-Eisawi DM (1998) Field guide to wild flowers of Jordan and neighbouring countries, 1st edn. Jordan Press Foundation “Al Rai”, Amman
Alikhanzade M, Tehranipour M, Khayatzade J (2014) The neuroprotective effect of alcoholic and aqueous extracts of Achillea biebersteinii leaves on spinal motoneurons denegation after sciatic nerve compression in rats. Adv Herb Med 1(1):8–16
Al-Jaber HI, Hammad HM, Al-Qudah MA, Abaza IF, Al-humaidi JYG, Abu-Zarga MH, Afifi FU (2014) Volatile oil composition and antiplatelet activity of Jordanian Achillea biebersteinii collected at different growth stages. J Essent Oil Bear Plants 17(4):584–598
doi: 10.1080/0972060X.2014.884762
Bader A, Flamini G, Cioni PL, Morelli I (2003) Essential oil composition of Achillea santolina L. and Achillea biebersteinii Afan. collected in Jordan. Flavour Fragr J 18(1):36–38
doi: 10.1002/ffj.1147
Bonjardim LR, Cunha ES, Guimarães AG, Santana MF, Oliveira MGB, Serafini MR, Araújo AAS, Antoniolli ÂR, Cavalcanti SCH, Santos MRV, Quintans-Júnior LJ (2012) Evaluation of the anti-inflammatory and antinociceptive properties of p-cymene in mice. Zeitschrift Fur Naturforschung C 67:15–21
doi: 10.1515/znc-2012-1-203
Calado GP, Lopes AJ, Costa Junior LM, Lima F, Silva LA, Pereira WS, Amaral FM, Garcia JB, Cartágenes Mdo S, Nascimento FR (2015) Chenopodium ambrosioides L. reduces synovial inflammation and pain in experimental osteoarthritis. PLoS ONE 10(11):e0141886
doi: 10.1371/journal.pone.0141886
Demirel MA, Suntar I, Ilhan M, Keles H, Akkol EK (2014) Experimental endometriosis remission in rats treated with Achillea biebersteinii Afan. histopathological evaluation and determination of cytokine levels. Eur J Obstet Gynecol Reprod Biol 175:172–177
doi: 10.1016/j.ejogrb.2014.01.011
Erbay MŞ, Anıl S, Melikoğlu G (2017) Plants used as painkiller in folk medicine in turkey-i stomachache. Marmara Pharm J 21(4):741–755
doi: 10.12991/mpj.2017.0
Garcia MD, Puerta R, Martinez S, Saenz MT (1997) Analgesic, antipyretic and antiinflammatory effects of Achillea ageratum. Phytother Res 11:376–379
doi: 10.1002/(SICI)1099-1573(199708)11:5<376::AID-PTR115>3.0.CO;2-M
Ghavami G, Sardari S, Shokrgozar MA (2010) Anticancerous potentials of Achillea species against selected cell lines. J Med Plants Res 4(22):2411–2417
Hamad YS (2012) Chemical composition and antimicrobial activity of the essential oils hydrodistilled from five Achillea species growing in Jordan. Msc. Thesis, The University of Jordan
Hammad HM, Albu C, Matar SA, Litescu SC, Al Jaber HI, Abualraghib AS, Afif FU (2013) Biological activities of the hydro-alcoholic and aqueous extracts of Achillea biebersteinii Afan. (Asteraceae) grown in Jordan. Afr J Pharm Pharmacol 7(25):1686–1694
doi: 10.5897/AJPP2012.1490
Hudaib MM, Tawaha KA, Mohammad MK, Assaf AM, Issa AY, Alali FQ, Aburjai TA, Bustanji YK (2011) Xanthine oxidase inhibitory activity of the methanolic extracts of selected Jordanian medicinal plants. Pharm Mag 7:320–324
doi: 10.4103/0973-1296.90413
Iscan G, Kirimer N, Kurkcuoglu M, Arabaci T, Kupeli E, Baser KH (2006) Biological activity and composition of the essential oils of Achillea schischkinii Sosn. and Achillea aleppica Dc. subsp. aleppica. J Agric Food Chem 54:170–173
doi: 10.1021/jf051644z
Karabay-Yavasoglu U, Karamenderes C, Baykan S, Apaydın S (2007) Antinociceptive and anti-inflammatory activities and acute toxicity of Achillea nobilis subsp. neilreichii extract in mice and rats. Pharm Biol 45:162–168
doi: 10.1080/13880200601113149
Kupeli E, Orhan I, Kusmenoglu S, Yesilada E (2007) Evaluation of anti-inflammatory and antinociceptive activity of five Anatolian Achillea species. Turk J Pharm Sci 4(2):89–99
Lauretti GR (2015) The evolution of spinal/epidural neostigmine in clinical application: thoughts after two decades. Saudi J Anest 9:71–81
doi: 10.4103/1658-354X.146319
Mazandarani M, Osia N, Ghafourian M (2015) Antioxidant activity and ethnopharmacological survey of Achillea biebersteinii Afan. in the treatment of dysmenorrhoea in traditional medicine of Golestan Province. Iran. Int J Women’s Health Reprod Sci 3(2):107–110
doi: 10.15296/ijwhr.2015.21
Melo FHC, Rios ERV, Rocha NFM, Citó MCO, Fernandes ML, de Sousa DP, de Vasconcelos SMM, de Sousa FCF (2012) Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice. J Pharm Pharmacol 64:1722–1729
doi: 10.1111/j.2042-7158.2012.01552.x
Mirahmadi SF, Norouzi R (2017) Chemical composition, phenolic content, free radical scavenging and antifungal activities of Achillea biebersteinii. Food Biosci 18:53–59
doi: 10.1016/j.fbio.2017.04.004
Mohamed AE-HH, Mohamed NS, Hamed AR, Hegazy M-EF (2016) Anti-inflammatory activity of highly oxygenated terpenoids from Achillea biebersteinii Afan. Zeitschrift für Naturforschung C 71:429–432
doi: 10.1515/znc-2016-0098
Mohammadhosseini M, Sarker SD, Akbarzadeh A (2017) Chemical composition of the essential oils and extracts of Achillea species and their biological activities: a review. J Ethnopharmacol 199:257–315
doi: 10.1016/j.jep.2017.02.010
Mojtahedin A, Tamaddonfard E, Zanbouri A (2009) Role of central muscarinic cholinergic receptors in the formalin-induced pain in rats. Indian J Pharmacol 41:144–147
doi: 10.4103/0253-7613.55207
Park S-H, Sim Y-B, Lee J-K, Kim S-M, Kang Y-J, Jung J-S, Suh H-W (2011) The analgesic effects and mechanisms of orally administered eugenol. Arch Pharm Res 34:501–507
doi: 10.1007/s12272-011-0320-z
Pires JM, Mendes FR, Negri G, Duarte-Almeida JM, Carlini EA (2009) Antinociceptive peripheral effect of Achillea millefolium L. and Artemisia vulgaris L.: both plants known popularly by brand names of analgesic drugs. Phytother Res 23(2):212–219
doi: 10.1002/ptr.2589
Radulovic NS, Dekic MS, Randelovic PJ, Stojanovic NM, Zarubica AR, Stojanovic-Radic ZZ (2012) Toxic essential oils: anxiolytic, antinociceptive and antimicrobial properties of the yarrow Achillea umbellata Sibth. et Sm. (Asteraceae) volatiles. Food Chem Toxicol 50(6):2016–2026
doi: 10.1016/j.fct.2012.03.047
Rezin GT, Scaini G, Ferreira GK, Cardoso MR, Gonçalves CL, Constantino LS, Deroza PF, Ghedim FV, Valvassori SS, Resende WR, Quevedo J, Zugno AI, Streck EL (2012) Inhibition of acetylcholinesterase activity in brain and behavioral analysis in adult rats after chronic administration of fenproporex. Metab Brain Dis 27:453–458
doi: 10.1007/s11011-012-9331-9
Rigo FK, Rossato MF, Trevisan G, De Prá SD, Ineu RP, Duarte MB, de Castro Junior CJ, Ferreira J, Gomez MV (2017) PhKv a toxin isolated from the spider venom induces antinociception by inhibition of cholinesterase activating cholinergic system. Scand J Pain 17:203–210
pubmed: 29107209
Saeidnia S, Gohari AR, Kiuchi F, Honda G (2005) In vitro anti-epimastigote activity of some Iranian medicinal plants. Iran J Pharm Res 2:101–103
Saeidnia S, Gohari AR, Mokhber-Dezfuli N, Kiuchi F (2011) A review on phytochemistry and medicinal properties of the genus Achillea. DARU J Pharm Sci 19:173–186
Sevindik HG, Güvenalp Z, Yerdelen KÖ, Yuca H, Demirezer LÖ (2015) Research on drug candidate anticholinesterase molecules from Achillea biebersteinii Afan using by molecular docking and in vitro methods. Med Chem Res 24:3794–3802
doi: 10.1007/s00044-015-1423-8
Zengin G, Aktumsek A, Ceylan R, Uysal S, Mocan A, Guler GO, Mahomoodally F, Glamocilija J, Ciric A, Sokovic M (2017) Shedding the light on biological and chemical fingerprints of three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia. Food Func 8(3):1152–1165
doi: 10.1039/C6FO01847E