Traffic-related Air Pollution and Pregnancy Loss.

Abortion, Spontaneous / epidemiology Boston / epidemiology Environmental Monitoring / methods Female Humans Israel / epidemiology Live Birth / epidemiology Nitrogen Dioxide / analysis Pregnancy Retrospective Studies Traffic-Related Pollution

Journal

Epidemiology (Cambridge, Mass.)
ISSN: 1531-5487
Titre abrégé: Epidemiology
Pays: United States
ID NLM: 9009644

Informations de publication

Date de publication:
01 2019
Historique:
pubmed: 11 9 2018
medline: 26 3 2019
entrez: 11 9 2018
Statut: ppublish

Résumé

Traffic-related air pollution has been linked to multiple adverse pregnancy outcomes. However, few studies have examined pregnancy loss, targeting losses identified by hospital records, a large limitation as it does not capture events not reported to the medical system. We used a novel variation of the time-series design to determine the association, and identify the critical window of vulnerability, between week-to-week traffic-related air pollution and conceptions resulting in live births, using nitrogen dioxide (NO2) as a traffic emissions tracer. We used information from all live births recorded at Beth Israel Deaconess Medical Center in Boston, MA (2000-2013) and all live births in Tel Aviv District, Israel (2010-2013). In Boston (68,969 live births), the strongest association was during the 15th week of gestation; for every 10 ppb of NO2 increase during that week, we observed a lower rate of live births (rate ratio [RR] = 0.87; 95% confidence interval [CI], 0.78, 0.97), using live birth-identified conceptions to infer pregnancy losses. In the Tel Aviv District (95,053 live births), the strongest estimate was during the 16th gestational week gestation (RR = 0.82; 95% CI, 0.76, 0.90 per 10 ppb of NO2). Using weekly conceptions ending in live birth rather than identified pregnancy losses, we comprehensively analyzed the relationship between air pollution and all pregnancy loss throughout gestation. The observed results, with remarkable similarity in two independent locations, suggest that higher traffic-related air pollution levels are associated with pregnancy loss, with strongest estimates between the 10th and 20th gestational weeks.

Sections du résumé

BACKGROUND
Traffic-related air pollution has been linked to multiple adverse pregnancy outcomes. However, few studies have examined pregnancy loss, targeting losses identified by hospital records, a large limitation as it does not capture events not reported to the medical system.
METHODS
We used a novel variation of the time-series design to determine the association, and identify the critical window of vulnerability, between week-to-week traffic-related air pollution and conceptions resulting in live births, using nitrogen dioxide (NO2) as a traffic emissions tracer. We used information from all live births recorded at Beth Israel Deaconess Medical Center in Boston, MA (2000-2013) and all live births in Tel Aviv District, Israel (2010-2013).
RESULTS
In Boston (68,969 live births), the strongest association was during the 15th week of gestation; for every 10 ppb of NO2 increase during that week, we observed a lower rate of live births (rate ratio [RR] = 0.87; 95% confidence interval [CI], 0.78, 0.97), using live birth-identified conceptions to infer pregnancy losses. In the Tel Aviv District (95,053 live births), the strongest estimate was during the 16th gestational week gestation (RR = 0.82; 95% CI, 0.76, 0.90 per 10 ppb of NO2).
CONCLUSIONS
Using weekly conceptions ending in live birth rather than identified pregnancy losses, we comprehensively analyzed the relationship between air pollution and all pregnancy loss throughout gestation. The observed results, with remarkable similarity in two independent locations, suggest that higher traffic-related air pollution levels are associated with pregnancy loss, with strongest estimates between the 10th and 20th gestational weeks.

Identifiants

DOI: 10.1097/EDE.0000000000000918 PMID: 30199416 PMC: PMC6269216
pubmed: 30199416
doi: 10.1097/EDE.0000000000000918
pmc: PMC6269216
mid: NIHMS1505976
doi:

Substances chimiques

Nitrogen Dioxide S7G510RUBH

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

4-10

Subventions

Organisme : NIEHS NIH HHS
ID : P30 ES000002
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES009089
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES026900
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007069
Pays : United States

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Auteurs

Marianthi-Anna Kioumourtzoglou (MA)

From the Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY.

Raanan Raz (R)

Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem Jerusalem, Israel.

Ander Wilson (A)

Department of Statistics, Colorado State University Fort Collins, CO.

Ronen Fluss (R)

Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem Jerusalem, Israel.

Ronit Nirel (R)

Department of Statistics, The Hebrew University of Jerusalem Jerusalem, Israel.

David M Broday (DM)

Faculty of Civil and Environmental Engineering, Technion, Israel Institute of Technology, Haifa, Israel.
Faculty of Civil and Environmental Engineering, Technion, Israel Institute of Technology, Haifa, Israel.

Michele R Hacker (MR)

Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, MA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health Boston, MA.

Thomas F McElrath (TF)

Division of Maternal-Fetal Medicine, Brigham & Women's Hospital, Harvard Medical School Boston, MA.

Itamar Grotto (I)

Ben-Gurion University of the Negev, Beer Sheva, Israel.
Public Health Services, Ministry of Health, Jerusalem, Israel.

Petros Koutrakis (P)

Department of Environmental Health, Harvard T.H. Chan School of Public Health Boston, MA.

Marc G Weisskopf (MG)

Department of Epidemiology, Harvard T.H. Chan School of Public Health Boston, MA.
Department of Environmental Health, Harvard T.H. Chan School of Public Health Boston, MA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Issue de la grossesse › Avortement spontané › Traffic-related Air Pollution and Pregnancy Loss.
questionsmedicales.fr › Régions géographiques › Villes › Boston › Traffic-related Air Pollution and Pregnancy Loss.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Surveillance de l'environnement › Traffic-related Air Pollution and Pregnancy Loss.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Traffic-related Air Pollution and Pregnancy Loss.
questionsmedicales.fr › Régions géographiques › Asie › Asie de l'Ouest › Moyen Orient › Israël › Traffic-related Air Pollution and Pregnancy Loss.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Issue de la grossesse › Naissance vivante › Traffic-related Air Pollution and Pregnancy Loss.
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Dioxyde d'azote › Traffic-related Air Pollution and Pregnancy Loss.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Traffic-related Air Pollution and Pregnancy Loss.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Traffic-related Air Pollution and Pregnancy Loss.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Pollution liée à la circulation › Traffic-related Air Pollution and Pregnancy Loss.