Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis.
Amino Acid Transport Systems, Basic
/ genetics
Animals
Azoxymethane
/ toxicity
Cell Line, Tumor
Cell Transformation, Neoplastic
/ chemically induced
Colonic Neoplasms
/ chemically induced
Inflammation
/ chemically induced
Inflammatory Bowel Diseases
/ chemically induced
Mice
Mice, Knockout
Neoplasm Proteins
/ genetics
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
29
03
2018
accepted:
17
08
2018
revised:
19
07
2018
pubmed:
12
9
2018
medline:
27
2
2019
entrez:
12
9
2018
Statut:
ppublish
Résumé
Solute carrier family 7 member 2 (SLC7A2, also known as CAT2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in wound repair. We have reported that both SLC7A2 expression and L-Arg availability are decreased in colonic tissues from inflammatory bowel disease patients and that mice lacking Slc7a2 exhibit a more severe disease course when exposed to dextran sulfate sodium (DSS) compared to wild-type (WT) mice. Here, we present evidence that SLC7A2 plays a role in modulating colon tumorigenesis in the azoxymethane (AOM)-DSS model of colitis-associated carcinogenesis (CAC). SLC7A2 was localized predominantly to colonic epithelial cells in WT mice. Utilizing the AOM-DSS model, Slc7a2
Identifiants
pubmed: 30202097
doi: 10.1038/s41388-018-0492-9
pii: 10.1038/s41388-018-0492-9
pmc: PMC6377304
mid: NIHMS1504343
doi:
Substances chimiques
Amino Acid Transport Systems, Basic
0
Neoplasm Proteins
0
Slc7a2 protein, mouse
156320-25-1
Azoxymethane
MO0N1J0SEN
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1067-1079Subventions
Organisme : NIDDK NIH HHS
ID : T32 DK007673
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : P01CA116087
Pays : International
Organisme : NCI NIH HHS
ID : R01 CA190612
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : T32DK007673
Pays : International
Organisme : NCCIH NIH HHS
ID : R01 AT004821
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : P01CA028842
Pays : International
Organisme : NIGMS NIH HHS
ID : T32 GM008554
Pays : United States
Organisme : U.S. Department of Veterans Affairs (VA)
ID : 1IK2BX002126
Pays : International
Organisme : NCI NIH HHS
ID : P50 CA236733
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : P30DK058404
Pays : International
Organisme : NIDDK NIH HHS
ID : R01 DK053620
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA028842
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : R01DK053620
Pays : International
Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : R01CA190612
Pays : International
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : F31DK10715
Pays : International
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : R01AT004821
Pays : International
Organisme : U.S. Department of Health & Human Services | NIH | National Center for Complementary and Integrative Health (NCCIH)
ID : R01AT004821
Pays : International
Organisme : NCI NIH HHS
ID : P01 CA116087
Pays : United States
Organisme : BLRD VA
ID : I01 BX001453
Pays : United States
Organisme : BLRD VA
ID : IK2 BX002126
Pays : United States
Organisme : U.S. Department of Veterans Affairs (VA)
ID : I01BX001453
Pays : International
Organisme : U.S. Department of Health & Human Services | NIH | National Center for Complementary and Integrative Health (NCCIH)
ID : 3R01AT004821-02S1
Pays : International
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