Venom characterization of the three species of Ophryacus and proteomic profiling of O. sphenophrys unveils Sphenotoxin, a novel Crotoxin-like heterodimeric β-neurotoxin.
Journal
Journal of proteomics
ISSN: 1876-7737
Titre abrégé: J Proteomics
Pays: Netherlands
ID NLM: 101475056
Informations de publication
Date de publication:
10 02 2019
10 02 2019
Historique:
received:
30
07
2018
revised:
02
09
2018
accepted:
07
09
2018
pubmed:
12
9
2018
medline:
27
2
2020
entrez:
12
9
2018
Statut:
ppublish
Résumé
Venoms of the three species of Ophryacus (O. sphenophrys, O. smaragdinus, and O. undulatus), a viperid genus endemic to Mexico, were analyzed for the first time in the present work. The three venoms lacked procoagulant activity on human plasma, but induced hemorrhage and were highly lethal to mice. These venoms also displayed proteolytic and phospholipase A
Identifiants
pubmed: 30205237
pii: S1874-3919(18)30343-9
doi: 10.1016/j.jprot.2018.09.002
pii:
doi:
Substances chimiques
Neurotoxins
0
Crotoxin
9007-40-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
196-207Informations de copyright
Copyright © 2018. Published by Elsevier B.V.