Effects of Gadodiamide and Gadoteric Acid on Rat Kidneys: A Comparative Study.
Animals
Chelating Agents
/ administration & dosage
Contrast Media
/ administration & dosage
Gadolinium DTPA
/ administration & dosage
Heterocyclic Compounds
/ administration & dosage
Immunohistochemistry
Infusions, Intravenous
Ions
Kidney
/ diagnostic imaging
Magnetic Resonance Imaging
Male
Organometallic Compounds
/ administration & dosage
Prospective Studies
Rats
Rats, Sprague-Dawley
contrast material
gadolinium
kidney
magnetic resonance imaging
rat
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
10
04
2018
revised:
02
07
2018
accepted:
03
07
2018
pubmed:
14
9
2018
medline:
24
3
2020
entrez:
14
9
2018
Statut:
ppublish
Résumé
Gadolinium-based contrast agents are complex chelates to provide contrast in NRI. However, recent studies have highlighted the deposition of free Gd To evaluate the histopathological and immunohistochemical changes on rat kidney tissue following both macrocyclic (gadoteric acid) and linear (gadodiamide) agents under the hypothesis that gadolinium-based contrast agents (GBCA) lead to toxic, free Gd The local Animal Care Committee approved the prospective animal study. Thirty-two healthy Sprague-Dawley male rats were administered 2 mmol/kg gadodiamide and gadoteric acid for the first 4 days for 5 weeks. Group 1 received no drug (control, n = 8) and Group 2 (n = 8) was administered 0.1 ml/kg saline. Group 3 was administered 0.1 mmol/kg gadodiamide and Group 4 (n = 8) was administered 2 mmol/kg gadoteric acid. Biochemical, histopathological, and immunohistochemical changes in testis kidney tissue were evaluated at the end of 10 weeks. Differences between groups were analyzed using the nonparametric Kruskal-Wallis test followed by one-way analysis of variance and the Tamhane test, also followed by Turkey's HSD test. Gadolinium increased serum urea, Ca GBCA administration causes significant histopathologic changes in kidney tissue. This study advocates additional investigation to assess the in vivo safety of GBCAs. 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:382-389.
Sections du résumé
BACKGROUND
Gadolinium-based contrast agents are complex chelates to provide contrast in NRI. However, recent studies have highlighted the deposition of free Gd
PURPOSE
To evaluate the histopathological and immunohistochemical changes on rat kidney tissue following both macrocyclic (gadoteric acid) and linear (gadodiamide) agents under the hypothesis that gadolinium-based contrast agents (GBCA) lead to toxic, free Gd
STUDY TYPE
The local Animal Care Committee approved the prospective animal study.
ANIMAL MODEL
Thirty-two healthy Sprague-Dawley male rats were administered 2 mmol/kg gadodiamide and gadoteric acid for the first 4 days for 5 weeks. Group 1 received no drug (control, n = 8) and Group 2 (n = 8) was administered 0.1 ml/kg saline. Group 3 was administered 0.1 mmol/kg gadodiamide and Group 4 (n = 8) was administered 2 mmol/kg gadoteric acid.
ASSESSMENT
Biochemical, histopathological, and immunohistochemical changes in testis kidney tissue were evaluated at the end of 10 weeks.
STATISTICAL TESTS
Differences between groups were analyzed using the nonparametric Kruskal-Wallis test followed by one-way analysis of variance and the Tamhane test, also followed by Turkey's HSD test.
RESULTS
Gadolinium increased serum urea, Ca
DATA CONCLUSION
GBCA administration causes significant histopathologic changes in kidney tissue. This study advocates additional investigation to assess the in vivo safety of GBCAs.
LEVEL OF EVIDENCE
1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:382-389.
Substances chimiques
Chelating Agents
0
Contrast Media
0
Heterocyclic Compounds
0
Ions
0
Organometallic Compounds
0
gadodiamide
84F6U3J2R6
gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
99J2XUF1JT
Gadolinium DTPA
K2I13DR72L
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
382-389Informations de copyright
© 2018 International Society for Magnetic Resonance in Medicine.