A comparative study of different aspects in manipulating ratio spectra used for the analysis of cefradine in the presence of its alkaline degradation product.
Cefradine
Continuous wavelet transform
Derivative continuous wavelet transform
Derivative ratio
Mean centering
Ratio difference
Savitsky–Golay filter
Spectrophotometry
Journal
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
ISSN: 1873-3557
Titre abrégé: Spectrochim Acta A Mol Biomol Spectrosc
Pays: England
ID NLM: 9602533
Informations de publication
Date de publication:
15 Jan 2019
15 Jan 2019
Historique:
received:
27
05
2018
revised:
13
08
2018
accepted:
26
08
2018
pubmed:
14
9
2018
medline:
19
12
2018
entrez:
14
9
2018
Statut:
ppublish
Résumé
Six stability-indicating UV-spectrophotometric methods manipulating ratio spectra were utilized for the analysis of cefradine in presence of its alkaline degradate. These methods are different forms of transformations; ratio difference, mean centering, derivative ratio using numerical differentiation, derivative ratio using Savitsky-Golay filter, continuous wavelet transform and derivative continuous wavelet transform. Water was used as a solvent and the linearity ranges were 6-26 μg/mL. Determination of accuracy and precision for the suggested procedures were executed. Assessment of specificity was run through analyzing laboratory prepared mixtures containing cefradine and its alkaline degradate. The suggested methods were useful for cefradine estimation in tablets. Statistically, the outputs obtained from the recommended and published methods reveal no significant differences.
Identifiants
pubmed: 30212663
pii: S1386-1425(18)30825-4
doi: 10.1016/j.saa.2018.08.049
pii:
doi:
Substances chimiques
Alkalies
0
Anti-Bacterial Agents
0
Cephradine
F1BC02I72W
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105-111Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.