Linking Cortical and Connectional Pathology in Schizophrenia.
Adult
Cerebral Cortex
/ diagnostic imaging
Diffusion Tensor Imaging
Female
Frontal Lobe
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net
/ diagnostic imaging
Neuroimaging
/ methods
Psychotic Disorders
/ diagnostic imaging
Schizophrenia
/ diagnostic imaging
White Matter
/ diagnostic imaging
computational psychiatry
cortical thickness
diffusion
multimodal imaging
neuropsychiatry
tractography
Journal
Schizophrenia bulletin
ISSN: 1745-1701
Titre abrégé: Schizophr Bull
Pays: United States
ID NLM: 0236760
Informations de publication
Date de publication:
18 06 2019
18 06 2019
Historique:
pubmed:
15
9
2018
medline:
1
7
2020
entrez:
15
9
2018
Statut:
ppublish
Résumé
Schizophrenia is associated with cortical thickness (CT) deficits and breakdown in white matter microstructure. Whether these pathological processes are related remains unclear. We used multimodal neuroimaging to investigate the relationship between regional cortical thinning and breakdown in adjacent infracortical white matter as a function of age and illness duration. Structural magnetic resonance and diffusion images were acquired in 218 schizophrenia patients and 167 age-matched healthy controls to map CT and fractional anisotropy in regionally adjacent infracortical white matter at various cortical depths. We found a robust and reproducible relationship between thickness and anisotropy deficits, which were inversely correlated across cortical regions (r = -.5, P < .0001): the most anisotropic infracortical white matter was found adjacent to regions with extensive cortical thinning. This pattern was evident in early (20 y: r = -.3, P = .005) and middle life (30 y: r = -.4, P = .004, 40 y: r = -.3, P = .04), but not beyond 50 years (P > .05). Frontal pathology contributed most to this pattern, with cortical thinning in patients compared to controls at all ages (P < .05); in contrast to initially elevated frontal white matter anisotropy in patients at 30 years, followed by rapid white matter decline with age (rate of annual decline; patients: 0.0012, controls 0.0006, P < .001). Our findings point to pathological dependencies between gray and white matter in a large sample of schizophrenia patients. We argue that elevated frontal anisotropy reflects regionally-specific, compensatory responses to cortical thinning, which are eventually overwhelmed with increasing illness duration.
Identifiants
pubmed: 30215783
pii: 5095722
doi: 10.1093/schbul/sby121
pmc: PMC6581130
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
911-923Informations de copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Références
Arch Gen Psychiatry. 2011 Sep;68(9):871-80
pubmed: 21893656
Am J Psychiatry. 1995 May;152(5):738-48
pubmed: 7726314
Physiol Rev. 2001 Apr;81(2):871-927
pubmed: 11274346
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9105-10
pubmed: 27457931
J Neurosci. 2012 Nov 28;32(48):17365-72
pubmed: 23197727
J Abnorm Psychol. 2001 Feb;110(1):40-8
pubmed: 11261398
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Mol Psychiatry. 2016 Dec;21(12):1672-1679
pubmed: 27698434
Alzheimers Res Ther. 2015 Jul 01;7(1):47
pubmed: 26136857
Neuroimage. 2010 Apr 15;50(3):970-83
pubmed: 20035887
Aust N Z J Psychiatry. 2010 Nov;44(11):1029-35
pubmed: 21034186
Neurotherapeutics. 2007 Jul;4(3):316-29
pubmed: 17599699
Schizophr Res Treatment. 2011;2011:325789
pubmed: 22937264
Neuroimage. 2010 Oct 15;53(1):1-15
pubmed: 20547229
Neuroimage. 2017 Jan 1;144(Pt A):58-73
pubmed: 27639350
Front Neurosci. 2011 Oct 19;5:120
pubmed: 22028680
Radiology. 2000 Sep;216(3):672-82
pubmed: 10966694
Aust N Z J Psychiatry. 2003 Aug;37(4):399-406
pubmed: 12873323
Magn Reson Med. 2008 Jun;59(6):1347-54
pubmed: 18506799
J Neurosci. 2013 Nov 20;33(47):18618-30
pubmed: 24259583
Neuron. 2003 Dec 4;40(5):885-95
pubmed: 14659088
Nat Rev Neurosci. 2003 Jun;4(6):469-80
pubmed: 12778119
Neurosci Biobehav Rev. 2013 Sep;37(8):1680-91
pubmed: 23769814
Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9
pubmed: 15148381
Schizophr Res. 2009 Sep;113(2-3):322-31
pubmed: 19616412
Transl Psychiatry. 2016 Apr 05;6:e774
pubmed: 27045844
Schizophr Res. 2012 Jul;138(2-3):136-42
pubmed: 22475381
Neuroimage. 2007 Apr 1;35(2):478-87
pubmed: 17292629
Neuroimage. 2011 Sep 1;58(1):41-9
pubmed: 21640837
Prog Neurobiol. 2011 Jan;93(1):13-24
pubmed: 20950668
Nat Rev Neurosci. 2015 Mar;16(3):159-72
pubmed: 25697159
Aust N Z J Psychiatry. 2017 May;51(5):455-476
pubmed: 27733710
Curr Opin Neurobiol. 2015 Feb;30:85-91
pubmed: 25464373
J Neurosci. 2015 Jun 17;35(24):9078-87
pubmed: 26085632
Mol Psychiatry. 2018 May;23(5):1261-1269
pubmed: 29038599
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
pubmed: 10984517
JAMA Psychiatry. 2013 Oct;70(10):1107-12
pubmed: 23925787
Schizophr Bull. 2014 May;40(3):665-74
pubmed: 23661633
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Psychol Med. 2017 Dec;47(16):2797-2810
pubmed: 28528586
Neuroimage. 2012 Jul 16;61(4):1000-16
pubmed: 22484410
Schizophr Res. 2007 Jul;93(1-3):13-22
pubmed: 17407804
Brain. 2007 Sep;130(Pt 9):2375-86
pubmed: 17698497
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
J Neurosci. 2015 Jan 7;35(1):267-86
pubmed: 25568120
Int J Neuropsychopharmacol. 2010 Aug;13(7):943-50
pubmed: 20350336
JAMA Psychiatry. 2014 Dec 1;71(12):1323-31
pubmed: 25271938
Arch Gen Psychiatry. 2003 Sep;60(9):878-88
pubmed: 12963669
Brain. 2008 Apr;131(Pt 4):945-61
pubmed: 18299296
J Neuropathol Exp Neurol. 2015 Mar;74(3):218-32
pubmed: 25668562
Hum Brain Mapp. 2017 Aug;38(8):3757-3770
pubmed: 28480992
Neuroimage. 2004 Jan;21(1):15-26
pubmed: 14741638