The New Face of the Lipid Droplet: Lipid Droplet Proteins.
conserved localization
lipid droplet
protein sorting
protein targeting pattern
proteome
Journal
Proteomics
ISSN: 1615-9861
Titre abrégé: Proteomics
Pays: Germany
ID NLM: 101092707
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
31
03
2018
revised:
13
08
2018
pubmed:
15
9
2018
medline:
28
4
2020
entrez:
15
9
2018
Statut:
ppublish
Résumé
The lipid droplet (LD) is an organelle with vital functions found in nearly all organisms. LD proteomic research has provided fundamentally important insights into this organelle's functions. The review provides a summary of LD proteomic studies conducted across diverse organisms and cell and tissue types. The accumulated proteomic data are reviewed for evidence of a protein targeting mechanism for the organelle. The hypotheses for several specific localization mechanisms based on what is known about targeting mechanisms for other organelles and vesicles are provided. Although the nature of the mechanism is not known, the functional data demonstrate that the targeting mechanism and, indeed, the organelle itself, is conserved from prokaryotes to eukaryotes. It is hoped that the review will help inspire further research leading to novel discoveries in the field.
Identifiants
pubmed: 30216670
doi: 10.1002/pmic.201700223
doi:
Substances chimiques
Lipid Droplet Associated Proteins
0
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1700223Informations de copyright
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.