Dorsal Cochlear Nucleus Fusiform-cell Plasticity is Altered in Salicylate-induced Tinnitus.
Animals
Auditory Pathways
/ drug effects
Cell Plasticity
/ drug effects
Cochlear Nucleus
/ physiopathology
Evoked Potentials, Auditory
/ drug effects
Evoked Potentials, Auditory, Brain Stem
/ drug effects
Guinea Pigs
Neuronal Plasticity
/ drug effects
Neurons
/ drug effects
Noise
Sodium Salicylate
/ pharmacology
Tinnitus
/ physiopathology
dorsal cochlear nucleus
fusiform cell
salicylate
spontaneous firing rate
stimulus-timing-dependent plasticity
tinnitus
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
21 05 2019
21 05 2019
Historique:
received:
02
07
2018
revised:
15
08
2018
accepted:
30
08
2018
pubmed:
16
9
2018
medline:
3
1
2020
entrez:
16
9
2018
Statut:
ppublish
Résumé
Following noise overexposure and tinnitus-induction, fusiform cells of the dorsal cochlear nucleus (DCN) show increased spontaneous firing rates (SFR), increased spontaneous synchrony and altered stimulus-timing-dependent plasticity (StDP), which correlate with behavioral measures of tinnitus. Sodium salicylate, the active ingredient in aspirin, which is commonly used to induce tinnitus, increases SFR and activates NMDA receptors in the ascending auditory pathway. NMDA receptor activation is required for StDP in many brain regions, including the DCN. Blocking NMDA receptors can alter StDP timing rules and decrease synchrony in DCN fusiform cells. Thus, systemic activation of NMDA receptors with sodium salicylate should elicit pathological changes to StDP, thereby increasing SFR and synchrony and induce tinnitus. Herein, we examined the action of salicylate in tinnitus generation in guinea pigs in vivo by measuring tinnitus using two behavioral measures and recording single-unit responses from DCN fusiform cells pre- and post-salicylate administration in the same animals. First, we show that animals administered salicylate show evidence of tinnitus using both behavioral paradigms, cross-validating the tests. Second, fusiform cells in animals with tinnitus showed increased SFR, synchrony and altered StDP timing rules, like animals with noise-induced tinnitus. These findings suggest that alterations to fusiform-cell plasticity are an essential component of tinnitus, regardless of induction technique.
Identifiants
pubmed: 30217755
pii: S0306-4522(18)30587-6
doi: 10.1016/j.neuroscience.2018.08.035
pmc: PMC6414292
mid: NIHMS1506416
pii:
doi:
Substances chimiques
Sodium Salicylate
WIQ1H85SYP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
170-181Subventions
Organisme : NIDCD NIH HHS
ID : P30 DC005188
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC004825
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH114244
Pays : United States
Organisme : NIDCD NIH HHS
ID : T32 DC000011
Pays : United States
Informations de copyright
Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.
Références
J Neurosci. 2013 Dec 11;33(50):19647-56
pubmed: 24336728
J Neurophysiol. 1996 Sep;76(3):1667-88
pubmed: 8890284
Sci Transl Med. 2018 Jan 3;10(422):
pubmed: 29298868
Neuroscience. 2010 Apr 14;166(4):1194-209
pubmed: 20096752
J Neurosci. 2016 Feb 10;36(6):2068-73
pubmed: 26865628
Hear Res. 2003 Sep;183(1-2):37-43
pubmed: 13679136
Front Syst Neurosci. 2012 Apr 20;6:28
pubmed: 22557950
Otolaryngol Head Neck Surg. 1999 Oct;121(4):457-62
pubmed: 10504604
Front Syst Neurosci. 2012 May 31;6:42
pubmed: 22666193
J Neurophysiol. 1990 Nov;64(5):1590-610
pubmed: 2283542
Front Neurol. 2015 Apr 28;6:88
pubmed: 25972836
Behav Neurosci. 1988 Dec;102(6):811-22
pubmed: 3214530
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7601-6
pubmed: 21502491
J Assoc Res Otolaryngol. 2008 Dec;9(4):417-35
pubmed: 18712566
Front Syst Neurosci. 2015 Aug 14;9:116
pubmed: 26321928
Elife. 2015 Aug 27;4:
pubmed: 26312501
J Neurosci Res. 2004 Dec 15;78(6):901-7
pubmed: 15495211
Hear Res. 2000 Oct;148(1-2):74-87
pubmed: 10978826
Neuron. 2000 Sep;27(3):611-22
pubmed: 11055442
Hear Res. 1998 Jun;120(1-2):86-108
pubmed: 9667434
Front Neural Circuits. 2015 Nov 20;9:75
pubmed: 26622224
Neuron. 1999 Sep;24(1):49-65, 111-25
pubmed: 10677026
J Neurosci. 1998 Dec 15;18(24):10464-72
pubmed: 9852584
Nat Neurosci. 2004 Jul;7(7):719-25
pubmed: 15208632
J Neurosci Methods. 2013 Mar 15;213(2):188-95
pubmed: 23291084
Exp Brain Res. 2003 Dec;153(4):477-85
pubmed: 13680048
Nat Neurosci. 2017 Jul;20(7):943-950
pubmed: 28530663
J Neurosci. 2003 May 1;23(9):3944-52
pubmed: 12736364
Trends Neurosci. 2004 Feb;27(2):104-10
pubmed: 15102490
J Comp Neurol. 1980 Jun 15;191(4):581-606
pubmed: 6158528
J Comp Neurol. 2005 Apr 4;484(2):191-205
pubmed: 15736230
Exp Brain Res. 1966;1(3):220-35
pubmed: 5920550
Science. 1997 Jan 10;275(5297):209-13
pubmed: 8985013
J Physiol. 2014 Nov 15;592(22):5065-78
pubmed: 25217380
Eur J Neurosci. 2008 Jan;27(1):155-68
pubmed: 18184319
Br J Pharmacol. 2009 Aug;157(8):1514-22
pubmed: 19594751
Hear Res. 2010 Aug;267(1-2):54-60
pubmed: 20430089
Hear Res. 2007 Apr;226(1-2):244-53
pubmed: 16904853
Hear Res. 2012 Jan;283(1-2):98-106
pubmed: 22085487
Nat Rev Neurol. 2016 Mar;12(3):150-60
pubmed: 26868680
J Neurosci. 2010 Nov 10;30(45):14972-9
pubmed: 21068300
PLoS One. 2013;8(3):e59828
pubmed: 23527274
J Comput Neurosci. 1999 Mar-Apr;6(2):169-84
pubmed: 10333161
J Comp Neurol. 1993 Jan 1;327(1):17-36
pubmed: 8432906
Behav Neurosci. 2006 Feb;120(1):188-95
pubmed: 16492129
Behav Brain Res. 1998 Dec;97(1-2):1-12
pubmed: 9867226
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9980-5
pubmed: 23716673
J Neurosci Methods. 2013 Oct 15;219(2):224-32
pubmed: 23933328
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14974-9
pubmed: 21896771
Hear Res. 2013 Jan;295:16-23
pubmed: 22688322
J Neurophysiol. 2015 Dec;114(6):3064-75
pubmed: 26289461
Acta Otorhinolaryngol Ital. 2014 Apr;34(2):79-93
pubmed: 24843217
J Neurophysiol. 1998 Oct;80(4):2113-20
pubmed: 9772265
J Neurophysiol. 2015 Feb 1;113(3):956-70
pubmed: 25392166
Hear Res. 2003 Sep;183(1-2):137-53
pubmed: 13679145
Am J Audiol. 2008 Dec;17(2):S185-92
pubmed: 18978200
Br J Audiol. 1989 Feb;23(1):53-62
pubmed: 2784987
Psychopharmacology (Berl). 2001 Jul;156(2-3):216-24
pubmed: 11549224
Neuroscience. 2007 Mar 16;145(2):715-26
pubmed: 17275194
Folia Allergol (Roma). 1972 Mar-Apr;19(2):126-8
pubmed: 5041973
Neuron. 2001 Aug 30;31(4):569-80
pubmed: 11545716
J Neurosci. 2012 Feb 1;32(5):1660-71
pubmed: 22302808
Stat Methods Med Res. 2004 Oct;13(5):347-61
pubmed: 15516030
J Neurosci. 2009 Apr 1;29(13):4210-7
pubmed: 19339615
Neuroscience. 2009 Dec 1;164(2):747-59
pubmed: 19699270
Hear Res. 2003 Jun;180(1-2):39-50
pubmed: 12782351
Otol Neurotol. 2010 Jul;31(5):823-31
pubmed: 20502380