A hyperactive mutant of interferon-regulatory factor 4.

Animals Humans Interferon Regulatory Factors / genetics Mutation T-Lymphocyte Subsets / immunology
IRF4 Mutation T cell differentiation Th17 Transcriptional activity

Journal

European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201

Informations de publication

Date de publication:
05 2019
Historique:
received: 31 01 2018
revised: 31 07 2018
accepted: 13 09 2018
pubmed: 16 9 2018
medline: 27 5 2020
entrez: 16 9 2018
Statut: ppublish

Résumé

We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferon-regulatory factor) C-terminus creates hyperactive IRF4. When introduced into IRF4-deficient CD4

Identifiants

DOI: 10.1002/eji.201847530 PMID: 30218581
pubmed: 30218581
doi: 10.1002/eji.201847530
doi:

Substances chimiques

Interferon Regulatory Factors 0
interferon regulatory factor-4 0

Types de publication

Letter Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

812-815

Informations de copyright

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Chol Ho Kang (CH)

Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.

Enno Hartmann (E)

Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.

Lisa Menke (L)

Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.

Daniel Staudenraus (D)

Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.

El-Fadil Abass (EF)

Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.

Hartmann Raifer (H)

Flow Cytometry Core Facility BMFZ¸ Philipps University Marburg, Marburg, Germany.

Alekya Porapu (A)

Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.

Bärbel Camara (B)

Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.

Anne Brüstle (A)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia.

Olaf Pinkenburg (O)

Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.

Maria Bieringer (M)

Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.

Michael Lohoff (M)

Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.
ORCID: 0000-0002-5204-4289

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A hyperactive mutant of interferon-regulatory factor 4.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A hyperactive mutant of interferon-regulatory factor 4.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de régulation d'interféron › A hyperactive mutant of interferon-regulatory factor 4.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › A hyperactive mutant of interferon-regulatory factor 4.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › A hyperactive mutant of interferon-regulatory factor 4.