Role of GPX4 in ferroptosis and its pharmacological implication.
Animals
Cell Death
/ drug effects
Fatty Acids, Unsaturated
/ metabolism
Ferroptosis
/ genetics
Humans
Iron
/ metabolism
Lipid Peroxidation
/ genetics
Mice
Neoplasms
/ drug therapy
Neurodegenerative Diseases
/ drug therapy
Phospholipid Hydroperoxide Glutathione Peroxidase
/ genetics
Small Molecule Libraries
/ therapeutic use
Cysteine metabolism
Ferritinophagy
GPX4
Lipid peroxidation
Non-apoptotic cell death
Regulated necrosis
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
08
08
2018
revised:
10
09
2018
accepted:
12
09
2018
pubmed:
17
9
2018
medline:
15
2
2020
entrez:
17
9
2018
Statut:
ppublish
Résumé
Ferroptosis is a non-apoptotic form of cell death characterized by iron-dependent lipid peroxidation and metabolic constraints. Dependence on NADPH/H
Identifiants
pubmed: 30219704
pii: S0891-5849(18)31593-4
doi: 10.1016/j.freeradbiomed.2018.09.014
pii:
doi:
Substances chimiques
Fatty Acids, Unsaturated
0
Small Molecule Libraries
0
Iron
E1UOL152H7
Phospholipid Hydroperoxide Glutathione Peroxidase
EC 1.11.1.12
glutathione peroxidase 4, mouse
EC 1.11.1.9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
144-152Informations de copyright
Copyright © 2018. Published by Elsevier Inc.