Phytofabricated silver nanoparticles of Phyllanthus emblica attenuated diethylnitrosamine-induced hepatic cancer via knock-down oxidative stress and inflammation.
Animals
Antioxidants
/ pharmacology
Carcinoma, Hepatocellular
/ chemically induced
Cytokines
/ metabolism
Diethylnitrosamine
/ pharmacology
Down-Regulation
/ drug effects
Female
Inflammation
/ drug therapy
Lipid Peroxidation
/ drug effects
Liver
/ drug effects
Liver Neoplasms
/ chemically induced
Male
Metal Nanoparticles
/ administration & dosage
NF-kappa B
/ metabolism
Oxidative Stress
/ drug effects
Phyllanthus emblica
/ chemistry
Plant Extracts
/ pharmacology
Rats
Rats, Wistar
Silver
/ administration & dosage
Diethylnitrosamine
Hepatocellular carcinoma
NF-kB
Phyllanthus emblica
Silver nanoparticles
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
02
08
2018
accepted:
27
08
2018
pubmed:
17
9
2018
medline:
28
11
2019
entrez:
17
9
2018
Statut:
ppublish
Résumé
Oxidative stress and inflammation play a pivotal role in the expansion and progression of hepatic cancer. Nanoparticle-based drug delivery can quickly enhance the restorative capability of hepatic cancer. Silver nanoparticles synthesized from plant source are of great importance due to their small size, economic, non-hazardous and different biomedical applications. In the current study, we have evaluated the impacts of oxidative stress and proinflammatory markers of biosynthesized silver nanoparticles of Phyllanthus emblica (PE) leaves against diethylnitrosamine-induced hepatocellular carcinoma (HCC) in wistar rats till 16 weeks with its underlying mechanism. The physico-chemical properties of biosynthesized silver nanoparticles were determined by ultra-visible spectroscopy, Fourier transform infrared spectroscopy, field emission scanning electron microscope, energy dispersive X-ray analysis, transmission electron microscopy and X-ray diffraction studies. Biofabricated silver nanoparticles (PEAgNPs) significantly enhanced the process of recovery from hepatic cancer in animal models, which was ascertained by increased body weight, reduced hepatic knobs on the outer surface of liver, downregulated serum biochemical parameters (ALT: 134.66 ± 2.60; AST: 120.33 ± 3.18; ALP: 153.33 ± 4.25; AFP: 167.33 ± 3.38), decreased hepatic lipid peroxidation (20.22 ± 1.74), increased membrane-bound enzymes (Na
Identifiants
pubmed: 30219979
doi: 10.1007/s10787-018-0525-6
pii: 10.1007/s10787-018-0525-6
doi:
Substances chimiques
Antioxidants
0
Cytokines
0
NF-kappa B
0
Plant Extracts
0
Diethylnitrosamine
3IQ78TTX1A
Silver
3M4G523W1G
Types de publication
Journal Article
Retracted Publication
Langues
eng
Sous-ensembles de citation
IM
Pagination
1037-1054Commentaires et corrections
Type : RetractionIn
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