Persistent Overexposure to N-Methyl-D-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes.
Animals
Aquaporin 4
/ metabolism
Astrocytes
/ metabolism
Calcium
/ metabolism
Cells, Cultured
Cerebral Cortex
/ metabolism
Down-Regulation
Glutamate-Ammonia Ligase
/ metabolism
Glutamic Acid
/ metabolism
Mice, Inbred C57BL
N-Methylaspartate
/ toxicity
Nerve Tissue Proteins
/ antagonists & inhibitors
Potassium Channels, Inwardly Rectifying
/ metabolism
RNA, Messenger
/ metabolism
Receptors, N-Methyl-D-Aspartate
/ antagonists & inhibitors
Aquaporin 4
Astrocytes
Excitotoxicity
GluN1
Glutamine synthetase
Kir4.1
NMDA receptor
Journal
Neurotoxicity research
ISSN: 1476-3524
Titre abrégé: Neurotox Res
Pays: United States
ID NLM: 100929017
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
11
08
2017
accepted:
07
09
2018
revised:
31
08
2018
pubmed:
17
9
2018
medline:
21
3
2019
entrez:
17
9
2018
Statut:
ppublish
Résumé
Astrocytes express N-methyl-D-aspartate (NMDA) receptor (NMDAR) but its functions in these cells are not well defined. This study shows that the sustained exposure (8-72 h) of mouse astrocytes to NMDA decreases the expression of the functional astroglia-specific proteins, glutamine synthetase (GS), and the water channel protein aquaporin-4 (AQP4) and also reduces GS activity. Similar to rat astrocytes (Obara-Michlewska et al. Neurochem Int 88:20-25, 2015), the exposure of mouse astrocytes to NMDA also decreased the expression of the inward rectifying potassium channel Kir4.1. NMDA failed to elicit the effects in those cells incubated in the absence of Ca
Identifiants
pubmed: 30220059
doi: 10.1007/s12640-018-9958-3
pii: 10.1007/s12640-018-9958-3
pmc: PMC6313349
doi:
Substances chimiques
Aqp4 protein, mouse
0
Aquaporin 4
0
Gprin1 protein, mouse
0
Kcnj10 (channel)
0
Nerve Tissue Proteins
0
Potassium Channels, Inwardly Rectifying
0
RNA, Messenger
0
Receptors, N-Methyl-D-Aspartate
0
Glutamic Acid
3KX376GY7L
N-Methylaspartate
6384-92-5
Glutamate-Ammonia Ligase
EC 6.3.1.2
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
271-280Subventions
Organisme : National Science Centre of the Republic of Poland
ID : 2013/08/M/NZ3/00869
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