New Insights into Measles Virus Brain Infections.

Amino Acid Substitution Animals Brain / virology Humans Measles / drug therapy Measles virus / pathogenicity Neurons / virology Protein Conformation Subacute Sclerosing Panencephalitis / drug therapy Viral Fusion Proteins / chemistry
CNS MIBE SSPE fusion measles virus paramyxovirus

Journal

Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916

Informations de publication

Date de publication:
02 2019
Historique:
received: 17 07 2018
revised: 22 08 2018
accepted: 24 08 2018
pubmed: 18 9 2018
medline: 18 12 2019
entrez: 18 9 2018
Statut: ppublish

Résumé

Measles virus (MeV) may persist in the brain, causing fatal neurodegenerative diseases, subacute sclerosing panencephalitis, and measles inclusion-body encephalitis. However, the mechanism of MeV propagation in the brain remains unexplained because human neurons affected by the diseases do not express the known receptors for MeV. Recent studies have revealed that certain changes in the ectodomain of the MeV fusion (F) protein play a key role in MeV spread in the brain. These changes destabilize the prefusion form of the F protein and render it hyperfusogenic, which in turn allows the virus to propagate in neurons. Based on crystal structures of the F protein, effective fusion inhibitors could be developed to treat these diseases.

Identifiants

DOI: 10.1016/j.tim.2018.08.010 PMID: 30220445
pubmed: 30220445
pii: S0966-842X(18)30194-X
doi: 10.1016/j.tim.2018.08.010
pii:
doi:

Substances chimiques

Viral Fusion Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

164-175

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Shumpei Watanabe (S)

Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan; Department of Microbiology, Faculty of Veterinary Medicine, Okayama University of Science, Ehime 794-8555, Japan. Electronic address: s-watanabe@vet.ous.ac.jp.

Yuta Shirogane (Y)

Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.

Yuma Sato (Y)

Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.

Takao Hashiguchi (T)

Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.

Yusuke Yanagi (Y)

Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: yyanagi@virology.med.kyushu-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Substitution d'acide aminé › New Insights into Measles Virus Brain Infections.
questionsmedicales.fr › Eucaryotes › Animaux › New Insights into Measles Virus Brain Infections.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › New Insights into Measles Virus Brain Infections.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › New Insights into Measles Virus Brain Infections.
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Mononegavirales › Infections à Paramyxoviridae › Infections à virus morbilleux › Rougeole › New Insights into Measles Virus Brain Infections.
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Morbillivirus › Virus de la rougeole › New Insights into Measles Virus Brain Infections.
questionsmedicales.fr › Cellules › Neurones › New Insights into Measles Virus Brain Infections.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › New Insights into Measles Virus Brain Infections.
questionsmedicales.fr › Maladies du système nerveux › Encéphalite › Encéphalite infectieuse › Encéphalite virale › Leucoencéphalite sclérosante subaigüe › New Insights into Measles Virus Brain Infections.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › New Insights into Measles Virus Brain Infections.