Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges.
Cerebellar ataxias
anti-GAD65Ab-associated cerebellar ataxia
gluten
ataxia
immune-mediated cerebellar ataxias
immunotherapy
opsoclonus myoclonus syndrome
paraneoplastic cerebellar degeneration
post-infectious cerebellitis
prognosis
therapy
treatment.
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
03
2018
revised:
06
07
2018
accepted:
03
09
2018
pubmed:
18
9
2018
medline:
11
4
2019
entrez:
18
9
2018
Statut:
ppublish
Résumé
Immune-mediated cerebellar ataxias (IMCAs), a clinical entity reported for the first time in the 1980s, include gluten ataxia (GA), paraneoplastic cerebellar degenerations (PCDs), antiglutamate decarboxylase 65 (GAD) antibody-associated cerebellar ataxia, post-infectious cerebellitis, and opsoclonus myoclonus syndrome (OMS). These IMCAs share common features with regard to therapeutic approaches. When certain factors trigger immune processes, elimination of the antigen( s) becomes a priority: e.g., gluten-free diet in GA and surgical excision of the primary tumor in PCDs. Furthermore, various immunotherapeutic modalities (e.g., steroids, immunoglobulins, plasmapheresis, immunosuppressants, rituximab) should be considered alone or in combination to prevent the progression of the IMCAs. There is no evidence of significant differences in terms of response and prognosis among the various types of immunotherapies. Treatment introduced at an early stage, when CAs or cerebellar atrophy is mild, is associated with better prognosis. Preservation of the "cerebellar reserve" is necessary for the improvement of CAs and resilience of the cerebellar networks. In this regard, we emphasize the therapeutic principle of "Time is Cerebellum" in IMCAs.
Identifiants
pubmed: 30221603
pii: CN-EPUB-93096
doi: 10.2174/1570159X16666180917105033
pmc: PMC6341499
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
33-58Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK026190
Pays : United States
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
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