Extracellular Matrix Determines Biomechanical Properties of Chondrospheres during Their Maturation
biomechanical properties
cartilage
chondrospheres
extracellular matrix
tissue spheroids
Journal
Cartilage
ISSN: 1947-6043
Titre abrégé: Cartilage
Pays: United States
ID NLM: 101518378
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
18
9
2018
medline:
6
8
2021
entrez:
18
9
2018
Statut:
ppublish
Résumé
Chondrospheres represent a variant of tissue spheroids biofabricated from chondrocytes. They are already being used in clinical trials for cartilage repair; however, their biomechanical properties have not been systematically investigated yet. The aim of our study was to characterize chondrospheres in long-term It has been demonstrated that the increase in chondrospheres secant modulus of elasticity is strongly associated with the synthesis and accumulation of extracellular matrix. Additionally, significant interplay has been found between biomechanical properties of tissue spheroids and their fusion kinetics in contrast to their spreading kinetics. Extracellular matrix is one of the main structural determinants of chondrospheres biomechanical properties during chondrogenic maturation
Identifiants
pubmed: 30221989
doi: 10.1177/1947603518798890
pmc: PMC7488948
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
521-531Références
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