The Role of Xenobiotic Receptors on Hepatic Glycolipid Metabolism.
Constitutive Androstane Receptor (CAR)
Energy metabolism
Glucose metabolism
Lipid metabolism
Pregnane X Receptor (PXR)
Xenobiotic receptors.
Journal
Current drug metabolism
ISSN: 1875-5453
Titre abrégé: Curr Drug Metab
Pays: Netherlands
ID NLM: 100960533
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
01
2018
revised:
13
03
2018
accepted:
20
08
2018
pubmed:
20
9
2018
medline:
25
7
2019
entrez:
20
9
2018
Statut:
ppublish
Résumé
PXR (Pregnane X Receptor) and CAR (Constitutive Androstane Receptor) are termed as xenobiotic receptors, which are known as core factors in regulation of the transcription of metabolic enzymes and drug transporters. However, accumulating evidence has shown that PXR and CAR exert their effects on energy metabolism through the regulation of gluconeogenesis, lipogenesis and β-oxidation. Therefore, in this review, we are trying to summary recent advances to show how xenobiotic receptors regulate energy metabolism. A structured search of databases has been performed by using focused review topics. According to conceptual framework, the main idea of research literature was summarized and presented. For introduction of each receptor, the general introduction and the critical functions in hepatic glucose and lipid metabolism have been included. Recent important studies have shown that CAR acts as a negative regulator of lipogenesis, gluconeogenesis and β -oxidation. PXR activation induces lipogenesis, inhibits gluconeogenesis and inhabits β-oxidation. In this review, the importance of xenobiotic receptors in hepatic glucose and lipid metabolism has been confirmed. Therefore, PXR and CAR may become new therapeutic targets for metabolic syndrome, including obesity and diabetes. However, further research is required to promote the clinical application of this new energy metabolism function of xenobiotic receptors.
Sections du résumé
BACKGROUND
BACKGROUND
PXR (Pregnane X Receptor) and CAR (Constitutive Androstane Receptor) are termed as xenobiotic receptors, which are known as core factors in regulation of the transcription of metabolic enzymes and drug transporters. However, accumulating evidence has shown that PXR and CAR exert their effects on energy metabolism through the regulation of gluconeogenesis, lipogenesis and β-oxidation. Therefore, in this review, we are trying to summary recent advances to show how xenobiotic receptors regulate energy metabolism.
METHODS
METHODS
A structured search of databases has been performed by using focused review topics. According to conceptual framework, the main idea of research literature was summarized and presented.
RESULTS
RESULTS
For introduction of each receptor, the general introduction and the critical functions in hepatic glucose and lipid metabolism have been included. Recent important studies have shown that CAR acts as a negative regulator of lipogenesis, gluconeogenesis and β -oxidation. PXR activation induces lipogenesis, inhibits gluconeogenesis and inhabits β-oxidation.
CONCLUSION
CONCLUSIONS
In this review, the importance of xenobiotic receptors in hepatic glucose and lipid metabolism has been confirmed. Therefore, PXR and CAR may become new therapeutic targets for metabolic syndrome, including obesity and diabetes. However, further research is required to promote the clinical application of this new energy metabolism function of xenobiotic receptors.
Identifiants
pubmed: 30227815
pii: CDM-EPUB-93130
doi: 10.2174/1389200219666180918152241
doi:
Substances chimiques
Constitutive Androstane Receptor
0
Glycolipids
0
Pregnane X Receptor
0
Receptors, Cytoplasmic and Nuclear
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Pagination
29-35Informations de copyright
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