Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease.
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
27
03
2018
accepted:
14
08
2018
pubmed:
20
9
2018
medline:
21
5
2020
entrez:
20
9
2018
Statut:
ppublish
Résumé
Cholestasis comprises aetiologically heterogeneous conditions characterized by accumulation of bile acids in the liver that actively contribute to liver damage. Sirtuin 1 (SIRT1) regulates liver regeneration and bile acid metabolism by modulating farnesoid X receptor (FXR); we here investigate its role in cholestatic liver disease. We determined SIRT1 expression in livers from patients with cholestatic disease, in two experimental models of cholestasis, as well as in human and murine liver cells in response to bile acid loading. SIRT1-overexpressing (SIRT
Identifiants
pubmed: 30229970
doi: 10.1002/hep.30275
pmc: PMC6492079
doi:
Substances chimiques
Bile Acids and Salts
0
SIRT1 protein, human
EC 3.5.1.-
Sirt1 protein, mouse
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
699-716Subventions
Organisme : Ministry of Economy and Competitiveness, Spain
ID : SAF2014-54658-R
Pays : International
Organisme : Asociación Española contra el Cáncer
Pays : International
Organisme : Gobierno Vasco-Departamento de Salud
ID : 2013111114
Pays : International
Organisme : Instituto de Salud Carlos III
ID : FIS PI12/00380
Pays : International
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/F/00044509
Pays : United Kingdom
Organisme : EITB Maratoia
ID : BIO15/CA/014
Pays : International
Organisme : NRP Science Links Seed Corn Fund
Pays : International
Organisme : BBVA Foundation
Pays : International
Organisme : Instituto de Salud Carlos III
ID : FIS PI15/01132
Pays : International
Organisme : Fondo Europeo de Desarrollo Regional
ID : CON14/00129
Pays : International
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/J004529/1
Pays : United Kingdom
Organisme : Ikerbaske foundation
ID : FIS PI12/00380
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PS12/00402
Pays : International
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/F/000PR10355
Pays : United Kingdom
Organisme : Camara de Comercio de Navarra
Pays : International
Organisme : Ikerbaske foundation
ID : FIS PI15/01132
Pays : International
Informations de copyright
© 2018 The Authors Hepatology published by Wiley Periodicals, Inc. on behalf of American Association for the Study of Liver Diseases.
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