Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization.
FSH receptor
In vitro fertilization
Infertility
LHCG receptor
Polymorphism
Journal
Journal of assisted reproduction and genetics
ISSN: 1573-7330
Titre abrégé: J Assist Reprod Genet
Pays: Netherlands
ID NLM: 9206495
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
18
06
2018
accepted:
11
09
2018
pubmed:
21
9
2018
medline:
4
4
2019
entrez:
21
9
2018
Statut:
ppublish
Résumé
The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF). A total of 665 women were consecutively enrolled for IVF during the period 2007-2016. Inclusion criteria were < 40 years of age, body mass index < 30 kg/m Women homozygous for S in both receptors combined (4S) had significantly higher live birth rate compared to those with other receptor variants when combining the first three IVF cycles (OR = 2.00, 95% CI [1.02, 3.92], p = 0.043). Cumulatively higher chance of live birth rate, during all IVF cycles, was also evident (HR = 1.89, 95% CI [1.00, 3.57], p = 0.049). Gonadotropin receptor variants are promising candidates for the prediction of the possibility to have a baby to take home after IVF treatment.
Identifiants
pubmed: 30232643
doi: 10.1007/s10815-018-1318-y
pii: 10.1007/s10815-018-1318-y
pmc: PMC6338601
doi:
Substances chimiques
FSHR protein, human
0
Receptors, FSH
0
Receptors, LH
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
29-38Subventions
Organisme : Interreg V, EU
ID : 20200407
Organisme : ALF governments grant
ID : F2014/354
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