Performance of the point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for follow-up after treatment of S. mansoni infection in Eritrean refugees.
Adult
Animals
Eritrea
Feces
/ parasitology
Female
Follow-Up Studies
Hematologic Tests
/ standards
Humans
Male
Point-of-Care Systems
/ standards
Praziquantel
/ therapeutic use
Refugees
Reproducibility of Results
Schistosoma mansoni
Schistosomiasis mansoni
/ blood
Sensitivity and Specificity
Switzerland
Urinalysis
/ standards
Young Adult
Migrants
Schistosomiasis
Screening
Specificity
Urine
Journal
Travel medicine and infectious disease
ISSN: 1873-0442
Titre abrégé: Travel Med Infect Dis
Pays: Netherlands
ID NLM: 101230758
Informations de publication
Date de publication:
Historique:
received:
24
07
2018
revised:
02
09
2018
accepted:
11
09
2018
pubmed:
22
9
2018
medline:
8
5
2019
entrez:
22
9
2018
Statut:
ppublish
Résumé
Point-of-care circulating cathodic antigen (POC-CCA) urine cassette testing has become a popular approach to screen for Schistosoma infection. Since the test is also increasingly used for following-up of treatment success, we assessed the assay's diagnostic accuracy after praziquantel treatment of S. mansoni infection among Eritrean refugees in Switzerland. In our preceding study, 107 asymptomatic Eritrean refugees in Switzerland were screened for schistosomiasis by stool microscopy, serology, and POC-CCA urine testing. Individuals screened positive by any method were treated with praziquantel and invited for a follow-up visit, repeating the same diagnostic procedures one year after treatment. The POC-CCA baseline and follow-up results were analyzed against the 'baseline microscopy positive cases' (= the most reliably true positive cases) and the 'baseline microscopy plus serology negative cases at baseline and follow-up' (= the most reliably true negative cases). Complete diagnostic baseline and follow-up sampling was available from 48 participants. Compared to most reliably true positive cases at baseline, POC-CCA testing had a sensitivity of 90%. Compared to most reliably true negative cases, POC-CCA testing had a specificity of 73.9%. We conclude that the POC-CCA urine test is valuable for screening but its use is not suitable for routine follow-up after treatment.
Sections du résumé
BACKGROUND
Point-of-care circulating cathodic antigen (POC-CCA) urine cassette testing has become a popular approach to screen for Schistosoma infection. Since the test is also increasingly used for following-up of treatment success, we assessed the assay's diagnostic accuracy after praziquantel treatment of S. mansoni infection among Eritrean refugees in Switzerland.
METHODS
In our preceding study, 107 asymptomatic Eritrean refugees in Switzerland were screened for schistosomiasis by stool microscopy, serology, and POC-CCA urine testing. Individuals screened positive by any method were treated with praziquantel and invited for a follow-up visit, repeating the same diagnostic procedures one year after treatment. The POC-CCA baseline and follow-up results were analyzed against the 'baseline microscopy positive cases' (= the most reliably true positive cases) and the 'baseline microscopy plus serology negative cases at baseline and follow-up' (= the most reliably true negative cases).
RESULTS
Complete diagnostic baseline and follow-up sampling was available from 48 participants. Compared to most reliably true positive cases at baseline, POC-CCA testing had a sensitivity of 90%. Compared to most reliably true negative cases, POC-CCA testing had a specificity of 73.9%.
CONCLUSION
We conclude that the POC-CCA urine test is valuable for screening but its use is not suitable for routine follow-up after treatment.
Identifiants
pubmed: 30236539
pii: S1477-8939(18)30236-9
doi: 10.1016/j.tmaid.2018.09.004
pii:
doi:
Substances chimiques
Praziquantel
6490C9U457
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-63Informations de copyright
Copyright © 2018. Published by Elsevier Ltd.