T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma.
Adult
Aged
Biomarkers
Biomarkers, Tumor
Computational Biology
/ methods
Female
Gene Expression Profiling
Humans
Immunohistochemistry
Lymphocyte Count
Lymphocytes, Tumor-Infiltrating
/ immunology
Male
Middle Aged
Neoplasm Staging
Prognosis
Proportional Hazards Models
T-Lymphocytes
/ immunology
Testicular Neoplasms
/ etiology
Transcriptome
Tumor Microenvironment
/ genetics
Journal
Haematologica
ISSN: 1592-8721
Titre abrégé: Haematologica
Pays: Italy
ID NLM: 0417435
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
18
06
2018
accepted:
19
09
2018
pubmed:
22
9
2018
medline:
6
5
2020
entrez:
22
9
2018
Statut:
ppublish
Résumé
Primary testicular lymphoma is a rare lymphoid malignancy, most often, histologically, representing diffuse large B-cell lymphoma. The tumor microenvironment and limited immune surveillance have a major impact on diffuse large B-cell lymphoma pathogenesis and survival, but the impact on primary testicular lymphoma is unknown. Here, the purpose of the study was to characterize the tumor microenvironment in primary testicular lymphoma, and associate the findings with outcome. We profiled the expression of 730 immune response genes in 60 primary testicular lymphomas utilizing the Nanostring platform, and used multiplex immunohistochemistry to characterize the immune cell phenotypes in the tumor tissue. We identified a gene signature enriched for T-lymphocyte markers differentially expressed between the patients. Low expression of the signature predicted poor outcome independently of the International Prognostic Index (progression-free survival: HR=2.810, 95%CI: 1.228-6.431,
Identifiants
pubmed: 30237271
pii: haematol.2018.200105
doi: 10.3324/haematol.2018.200105
pmc: PMC6355505
doi:
Substances chimiques
Biomarkers
0
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
338-346Informations de copyright
Copyright © 2019 Ferrata Storti Foundation.
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