Clinical and genetic characteristics of abnormal glucose tolerance in Japanese women in the first year after gestational diabetes mellitus.
Adult
Biomarkers
/ blood
Blood Glucose
/ analysis
Diabetes Mellitus, Type 2
/ complications
Diabetes, Gestational
/ physiopathology
Female
Follow-Up Studies
Glucose Intolerance
/ blood
Glucose Tolerance Test
Glycated Hemoglobin
/ analysis
Humans
Japan
Middle Aged
Polymorphism, Single Nucleotide
Pregnancy
Prognosis
Retrospective Studies
Young Adult
Gestational diabetes
Glucose tolerance test
Single-nucleotide polymorphism
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
13
03
2018
revised:
20
07
2018
accepted:
17
09
2018
pubmed:
22
9
2018
medline:
1
10
2019
entrez:
22
9
2018
Statut:
ppublish
Résumé
Risk factors of type 2 diabetes mellitus in Japanese women with recent gestational diabetes mellitus are unknown. The objective of the present study was to investigate the clinical and genetic characteristics associated with postpartum abnormal glucose tolerance in Japanese women with gestational diabetes mellitus. A total of 213 Japanese women with recent gestational diabetes mellitus who underwent a postpartum 2-h oral glucose tolerance test were investigated. The association between antepartum clinical characteristics and postpartum abnormal glucose tolerance (diabetes or prediabetes based on the Japan Diabetes Society criteria) was examined. Frequencies of 45 known type 2 diabetes mellitus-associated genetic variants were also compared between women with and without postpartum abnormal glucose tolerance. A total of 59 women showed postpartum abnormal glucose tolerance (prediabetes, n = 51; diabetes, n = 8). Plasma glucose levels at 1 or 2 h, the insulinogenic index and the insulin secretion-sensitivity index-2 of the antepartum oral glucose tolerance test were independent of postpartum abnormal glucose tolerance risk factors (P = 0.006, P = 0.00002, P = 0.01 and P = 0.006, respectively). Four genetic variants (rs266729 [ADIPOQ], rs6017317 [HNF4A], rs5215 [KCNJ11] and rs7177055 [HMG20A]) showed a nominally significant association with postpartum abnormal glucose tolerance (P < 0.05, respectively). Among these, three were related to insulin secretion. Postpartum abnormal glucose tolerance risk significantly increased with increasing risk-allele number (P = 0.0005; odds ratio 1.91). Clinical features and genetic variants related to impaired insulin secretion are risk factors of postpartum abnormal glucose tolerance in Japanese women with recent gestational diabetes mellitus.
Identifiants
pubmed: 30239167
doi: 10.1111/jdi.12935
pmc: PMC6497595
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Glycated Hemoglobin A
0
hemoglobin A1c protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
817-826Subventions
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : 16gm0510011h0205
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : 16ek0109067h0003
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : 16gk0110013s0801
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : 16gk0110018s0601
Organisme : KAKENHI
ID : 26293365
Organisme : KAKENHI
ID : 26462500
Organisme : NCCHD of Japan
ID : 26-13
Informations de copyright
© 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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