Pathological significance of urinary complement activation in diabetic nephropathy: A full view from the development of the disease.
Biomarkers
/ blood
Case-Control Studies
Complement Activation
Complement C3a
/ urine
Complement C5a
/ urine
Complement Membrane Attack Complex
/ urine
Diabetes Mellitus, Type 2
/ complications
Diabetic Nephropathies
/ etiology
Disease Progression
Female
Follow-Up Studies
Humans
Kidney Tubules
/ injuries
Male
Middle Aged
Prognosis
Diabetic nephropathy
Tubular injury
Urinary complement activation products
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
09
05
2018
revised:
30
08
2018
accepted:
17
09
2018
pubmed:
22
9
2018
medline:
1
10
2019
entrez:
22
9
2018
Statut:
ppublish
Résumé
The aim of the present study was to obtain a full view of the changes of urinary complement activation products in the development of diabetic nephropathy and explore their possible significance in the disease process. A total of 62 patients at different stages of diabetic nephropathy, 20 diabetes patients without nephropathy and 20 healthy persons were enrolled. Urinary complement activation products, including C3a, C5a and C5b-9, were measured, and their associations with the progression of the disease were analyzed. The urinary complement activation products increased markedly since the proteinuria stage, and were parallel with the progression of diabetic nephropathy. More severe renal tubular damage was observed in patients with higher levels of urinary complement activation products. The urinary complement activation products levels correlated closely with renal tubulointerstitial injury score and relative tubular interstitial volume. Multivariate regression analysis showed that elevated urinary complement activation products were independent risk factors for tubular injury in diabetic nephropathy patients. Urinary complement activation might have a role in renal tubular interstitial injury in patients with diabetic nephropathy, especially in patients at a later stage of the disease.
Identifiants
pubmed: 30239170
doi: 10.1111/jdi.12934
pmc: PMC6497774
doi:
Substances chimiques
Biomarkers
0
Complement Membrane Attack Complex
0
Complement C3a
80295-42-7
Complement C5a
80295-54-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
738-744Subventions
Organisme : National Natural Science Foundation of China
ID : 81370828
Informations de copyright
© 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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