Azithromycin Susceptibility Among Neisseria gonorrhoeae Isolates and Seasonal Macrolide Use.


Journal

The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675

Informations de publication

Date de publication:
29 01 2019
Historique:
received: 16 07 2018
accepted: 12 09 2018
pubmed: 22 9 2018
medline: 13 11 2019
entrez: 22 9 2018
Statut: ppublish

Résumé

Rising azithromycin nonsusceptibility among Neisseria gonorrhoeae isolates threatens current treatment recommendations, but the cause of this rise is not well understood. We performed an ecological study of seasonal patterns in macrolide use and azithromycin resistance in N. gonorrhoeae, finding that population-wide macrolide use is associated with increased azithromycin nonsusceptibility. These results, indicative of bystander selection, have implications for antibiotic prescribing guidelines.

Identifiants

pubmed: 30239814
pii: 5098400
doi: 10.1093/infdis/jiy551
pmc: PMC6350947
doi:

Substances chimiques

Anti-Bacterial Agents 0
Macrolides 0
Azithromycin 83905-01-5

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

619-623

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI132606
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM088558
Pays : United States

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Auteurs

Scott W Olesen (SW)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

Elizabeth A Torrone (EA)

Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

John R Papp (JR)

Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

Robert D Kirkcaldy (RD)

Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

Marc Lipsitch (M)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

Yonatan H Grad (YH)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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Classifications MeSH