Attenuated Post-Movement Beta Rebound Associated With Schizotypal Features in Healthy People.
Adult
Beta Rhythm
/ physiology
Cerebral Cortex
/ physiopathology
Electromyography
Female
Humans
Individuality
Magnetic Resonance Imaging
Magnetoencephalography
Male
Middle Aged
Psychomotor Performance
/ physiology
Schizophrenia
/ physiopathology
Schizotypal Personality Disorder
/ physiopathology
Young Adult
individual differences
magnetoencephalography
psychosis
schizophrenia
schizotypal personality disorder
schizotypy
Journal
Schizophrenia bulletin
ISSN: 1745-1701
Titre abrégé: Schizophr Bull
Pays: United States
ID NLM: 0236760
Informations de publication
Date de publication:
18 06 2019
18 06 2019
Historique:
pubmed:
22
9
2018
medline:
1
7
2020
entrez:
22
9
2018
Statut:
ppublish
Résumé
Schizophrenia and schizotypal personality disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the 2 conditions. However, schizotypy is a heterogeneous facet of personality in the healthy population and so may be seen as a bridge between health and mental illness. Neural evidence for such a continuity would have implications for the characterization and treatment of schizophrenia. Based on our previous work identifying a relationship between symptomology in schizophrenia and abnormal movement-induced electrophysiological response (the post-movement beta rebound [PMBR]), we predicted that if subclinical schizotypy arises from similar neural mechanisms to schizophrenia, schizotypy in healthy individuals would be associated with reduced PMBR. One-hundred sixteen participants completed a visuomotor task while their neural activity was recorded by magnetoencephalography. Partial correlations were computed between a measure of PMBR extracted from left primary motor cortex and scores on the Schizotypal Personality Questionnaire (SPQ), a self-report measure of schizotypal personality. Correlations between PMBR and SPQ factor scores measuring cognitive-perceptual, interpersonal and disorganization dimensions of schizotypy were also computed. Effects of site, age, and sex were controlled for. We found a significant negative correlation between total SPQ score and PMBR. This was most strongly mediated by variance shared between interpersonal and disorganization factor scores. These findings indicate a continuum of neural deficit between schizotypy and schizophrenia, with diminution of PMBR, previously reported in schizophrenia, also measurable in individuals with schizotypal features, particularly disorganization and impaired interpersonal relations.
Identifiants
pubmed: 30239878
pii: 5095481
doi: 10.1093/schbul/sby117
pmc: PMC6581139
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
883-891Subventions
Organisme : Medical Research Council
ID : MR/K005464/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K020803/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K501086
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J01186X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M006301/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M009122/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0901321
Pays : United Kingdom
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
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