Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples.
Brain
/ metabolism
Chromosomes, Human, Pair 2
/ genetics
CpG Islands
/ genetics
Cytoskeletal Proteins
/ genetics
DNA Methylation
/ genetics
DNA, Intergenic
/ genetics
Depressive Disorder, Major
/ blood
Epigenome
/ genetics
Female
Genome-Wide Association Study
Humans
Male
Middle Aged
Receptors, GABA-B
/ genetics
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
15
12
2017
accepted:
08
08
2018
revised:
26
06
2018
pubmed:
23
9
2018
medline:
10
3
2021
entrez:
23
9
2018
Statut:
ppublish
Résumé
We present the first large-scale methylome-wide association studies (MWAS) for major depressive disorder (MDD) to identify sites of potential importance for MDD etiology. Using a sequencing-based approach that provides near-complete coverage of all 28 million common CpGs in the human genome, we assay methylation in MDD cases and controls from both blood (N = 1132) and postmortem brain tissues (N = 61 samples from Brodmann Area 10, BA10). The MWAS for blood identified several loci with P ranging from 1.91 × 10
Identifiants
pubmed: 30242228
doi: 10.1038/s41380-018-0247-6
pii: 10.1038/s41380-018-0247-6
pmc: PMC6428621
mid: NIHMS1503247
doi:
Substances chimiques
Cytoskeletal Proteins
0
DNA, Intergenic
0
GABBR2 protein, human
0
RUFY3 protein, human
0
Receptors, GABA-B
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1344-1354Subventions
Organisme : NIMH NIH HHS
ID : RC2 MH089951
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH081802
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089995
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026057
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH099110
Pays : United States
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