Co-existence of ossification of the nuchal ligament is associated with severity of ossification in the whole spine in patients with cervical ossification of the posterior longitudinal ligament -A multi-center CT study.

Adult Aged Aged, 80 and over Cervical Vertebrae / diagnostic imaging Female Humans Longitudinal Ligaments / diagnostic imaging Male Middle Aged Ossification of Posterior Longitudinal Ligament / complications Ossification, Heterotopic / complications Severity of Illness Index Tomography, X-Ray Computed / methods

Journal

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
ISSN: 1436-2023
Titre abrégé: J Orthop Sci
Pays: Japan
ID NLM: 9604934

Informations de publication

Date de publication:
Jan 2019
Historique:
received: 19 03 2018
revised: 02 08 2018
accepted: 15 08 2018
pubmed: 24 9 2018
medline: 8 5 2019
entrez: 24 9 2018
Statut: ppublish

Résumé

Previous studies have shown that patients with cervical ossification of the posterior longitudinal ligament (OPLL) often have co-existing ossification of the nuchal ligament (ONL). However, no studies have focused on ONL and its relevance to the severity of OPLL or ossification of other spinal ligaments, such as anterior longitudinal ligament (OALL), ligamentum flavum (OLF), and supraspinous/interspinous ligament (OSIL). In this multicenter study, we investigated ossification of the spinal ligaments in the whole spine computed tomography (CT) images of 233 cervical OPLL patients. The severity of ossification was evaluated using ossification index for each spinal ligament, calculated as the sum of the level of ossification. We compared the severity of ossification in each spinal ligament between patients with ONL and those without ONL. Furthermore, we investigated how the number of segments, where ONL exists, affects the severity of ossification in each spinal ligament. One hundred thirty patients (55.8%) had co-existing ONL in the cervical OPLL patients included in this study. The ONL (+) group included more male and aged patients. The cervical ossification indexes of OPLL and OALL were higher in ONL (+) patients than in ONL (-) patients. The thoracolumbar ossification indexes of OALL and OSIL were also higher in ONL (+) patients. Logistic regression analysis revealed that age, gender and cervical OA-index were independent factors correlating to the existence of ONL. In the cervical spine, both the ossification indexes of OALL and OPLL increased as the levels of ONL increased. Similarly, in the thoracolumbar spine, both the ossification indexes of OALL and OSIL were increased as the levels of cervical ONL increased. In the multiple regression analysis, cervical OA-index and thoracolumbar OSI-index showed significant correlation with the number of ONL levels. Co-existence of ONL in cervical OPLL patients was associated with the severity of spinal hyperostosis especially in cervical OPLL, OALL, thoracolumbar OALL and OSIL.

Sections du résumé

BACKGROUND BACKGROUND
Previous studies have shown that patients with cervical ossification of the posterior longitudinal ligament (OPLL) often have co-existing ossification of the nuchal ligament (ONL). However, no studies have focused on ONL and its relevance to the severity of OPLL or ossification of other spinal ligaments, such as anterior longitudinal ligament (OALL), ligamentum flavum (OLF), and supraspinous/interspinous ligament (OSIL).
METHODS METHODS
In this multicenter study, we investigated ossification of the spinal ligaments in the whole spine computed tomography (CT) images of 233 cervical OPLL patients. The severity of ossification was evaluated using ossification index for each spinal ligament, calculated as the sum of the level of ossification. We compared the severity of ossification in each spinal ligament between patients with ONL and those without ONL. Furthermore, we investigated how the number of segments, where ONL exists, affects the severity of ossification in each spinal ligament.
RESULTS RESULTS
One hundred thirty patients (55.8%) had co-existing ONL in the cervical OPLL patients included in this study. The ONL (+) group included more male and aged patients. The cervical ossification indexes of OPLL and OALL were higher in ONL (+) patients than in ONL (-) patients. The thoracolumbar ossification indexes of OALL and OSIL were also higher in ONL (+) patients. Logistic regression analysis revealed that age, gender and cervical OA-index were independent factors correlating to the existence of ONL. In the cervical spine, both the ossification indexes of OALL and OPLL increased as the levels of ONL increased. Similarly, in the thoracolumbar spine, both the ossification indexes of OALL and OSIL were increased as the levels of cervical ONL increased. In the multiple regression analysis, cervical OA-index and thoracolumbar OSI-index showed significant correlation with the number of ONL levels.
CONCLUSIONS CONCLUSIONS
Co-existence of ONL in cervical OPLL patients was associated with the severity of spinal hyperostosis especially in cervical OPLL, OALL, thoracolumbar OALL and OSIL.

Identifiants

DOI: 10.1016/j.jos.2018.08.009 PMID: 30243519
pubmed: 30243519
pii: S0949-2658(18)30233-1
doi: 10.1016/j.jos.2018.08.009
pii:
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

35-41

Informations de copyright

Copyright © 2018 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.

Auteurs

Toshitaka Yoshii (T)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo Ward, Tokyo 113-8519, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan. Electronic address: yoshii.orth@tmd.ac.jp.

Takashi Hirai (T)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo Ward, Tokyo 113-8519, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Akio Iwanami (A)

Department of Orthopedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku Ward, Tokyo 160-8582, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Narihito Nagoshi (N)

Department of Orthopedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku Ward, Tokyo 160-8582, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Kazuhiro Takeuchi (K)

Department of Orthopedic Surgery, National Hospital Organization Okayama Medical Center, 1711-1 Tamasu, Okayama, Okayama 701-1154, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Kanji Mori (K)

Department of Orthopedic Surgery, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Shiga 520-2192, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Tsuyoshi Yamada (T)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo Ward, Tokyo 113-8519, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Shoji Seki (S)

Department of Orthopedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Takashi Tsuji (T)

Department of Orthopedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku Ward, Tokyo 160-8582, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Kanehiro Fujiyoshi (K)

Department of Orthopedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku Ward, Tokyo 160-8582, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Mitsuru Furukawa (M)

Department of Orthopedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku Ward, Tokyo 160-8582, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Soraya Nishimura (S)

Department of Orthopedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku Ward, Tokyo 160-8582, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Kanichiro Wada (K)

Department of Orthopedic Surgery, Hirosaki University Graduate School of Medicine, 53 Honcho, Hirosaki, Aomori 036-8203, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Masao Koda (M)

Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo Ward, Chiba, Chiba 260-0856, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Takeo Furuya (T)

Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo Ward, Chiba, Chiba 260-0856, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Yukihiro Matsuyama (Y)

Department of Orthopedic Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3125, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Tomohiko Hasegawa (T)

Department of Orthopedic Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3125, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Katsushi Takeshita (K)

Department of Orthopedics, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Atsushi Kimura (A)

Department of Orthopedics, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Masahiko Abematsu (M)

Department of Orthopedic Surgery, Graduate School of Medicine and Dental Science, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima 890-8520, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Hirotaka Haro (H)

Department of Orthopedic Surgery, University of Yamanashi, 1110 Shimokato, Chuo Ward, Yamanashi 409-3898, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Tetsuro Ohba (T)

Department of Orthopedic Surgery, University of Yamanashi, 1110 Shimokato, Chuo Ward, Yamanashi 409-3898, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Masahiko Watanabe (M)

Department of Orthopedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Hiroyuki Katoh (H)

Department of Orthopedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Kei Watanabe (K)

Department of Orthopedic Surgery, Niigata University Medicine and Dental General Hospital, 1-754 Asahimachidori, Chuo Ward, Niigata, Niigata 951-8520, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Hiroshi Ozawa (H)

Department of Orthopaedic Surgery, Tohoku Medical and Pharmaceutical University, 1-12-1 Fukumuro Miyaginoku, Sendai 983-8512, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Haruo Kanno (H)

Department of Orthopaedic Surgery, Tohoku University School of Medicine, 1-1 Seiryomachi, Aoba Ward, Sendai, Miyagi 980-8574, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Shiro Imagama (S)

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa Ward, Nagoya, Aichi 466-0065, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Kei Ando (K)

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa Ward, Nagoya, Aichi 466-0065, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Shunsuke Fujibayashi (S)

Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo Ward, Kyoto, Kyoto 606-8507, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Morio Matsumoto (M)

Department of Orthopedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku Ward, Tokyo 160-8582, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Masaya Nakamura (M)

Department of Orthopedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku Ward, Tokyo 160-8582, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Masashi Yamazaki (M)

Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, 2-1-1 Amakubo, Tsukuba, Ibaraki 305-8576, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Atsushi Okawa (A)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo Ward, Tokyo 113-8519, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

Yoshiharu Kawaguchi (Y)

Department of Orthopedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan; Japanese Multicenter Research Organization for Ossification of the Spinal Ligament, Japan.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Co-existence of ossification of the nuchal...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Co-existence of ossification of the nuchal...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Co-existence of ossification of the nuchal...
questionsmedicales.fr › Appareil locomoteur › Squelette › Rachis › Vertèbres cervicales › Co-existence of ossification of the nuchal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Co-existence of ossification of the nuchal...
questionsmedicales.fr › Tissus › Tissu conjonctif › Ligaments › Ligaments articulaires › Ligaments longitudinaux › Co-existence of ossification of the nuchal...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Co-existence of ossification of the nuchal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Ossification hétérotopique › Ossification du ligament longitudinal postérieur › Co-existence of ossification of the nuchal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Ossification hétérotopique › Co-existence of ossification of the nuchal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Co-existence of ossification of the nuchal...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Co-existence of ossification of the nuchal...