Social brain, social dysfunction and social withdrawal.

Affect Alzheimer Disease / physiopathology Brain / physiopathology Depressive Disorder, Major / physiopathology Humans Interpersonal Relations Mental Disorders / physiopathology Neural Pathways / physiopathology Schizophrenia / physiopathology Schizophrenic Psychology Social Isolation Social Perception Theory of Mind
Alzheimer’s disease Major depression disorder Neurobiology Schizophrenia Social brain Social cognition Social dysfunction Social functioning Social impairments Social withdrawal

Journal

Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090

Informations de publication

Date de publication:
02 2019
Historique:
received: 01 08 2017
revised: 31 05 2018
accepted: 17 09 2018
pubmed: 24 9 2018
medline: 30 6 2019
entrez: 24 9 2018
Statut: ppublish

Résumé

The human social brain is complex. Current knowledge fails to define the neurobiological processes underlying social behaviour involving the (patho-) physiological mechanisms that link system-level phenomena to the multiple hierarchies of brain function. Unfortunately, such a high complexity may also be associated with a high susceptibility to several pathogenic interventions. Consistently, social deficits sometimes represent the first signs of a number of neuropsychiatric disorders including schizophrenia (SCZ), Alzheimer's disease (AD) and major depressive disorder (MDD) which leads to a progressive social dysfunction. In the present review we summarize present knowledge linking neurobiological substrates sustaining social functioning, social dysfunction and social withdrawal in major psychiatric disorders. Interestingly, AD, SCZ, and MDD affect the social brain in similar ways. Thus, social dysfunction and its most evident clinical expression (i.e., social withdrawal) may represent an innovative transdiagnostic domain, with the potential of being an independent entity in terms of biological roots, with the perspective of targeted interventions.

Identifiants

DOI: 10.1016/j.neubiorev.2018.09.012 PMID: 30244163
pubmed: 30244163
pii: S0149-7634(18)30195-7
doi: 10.1016/j.neubiorev.2018.09.012
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

10-33

Informations de copyright

Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Stefano Porcelli (S)

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Italy. Electronic address: stefano.porcelli5@unibo.it.

Nic Van Der Wee (N)

Leiden Institute for Brain and Cognition/Psychiatric Neuroimaging, Department of Psychiatry, Leiden University Medical Center, the Netherlands.

Steven van der Werff (S)

Leiden Institute for Brain and Cognition/Psychiatric Neuroimaging, Department of Psychiatry, Leiden University Medical Center, the Netherlands.

Moji Aghajani (M)

VU University Medical Center, Department of Psychiatry, Amsterdam, the Netherlands.

Jeffrey C Glennon (JC)

Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University, the Netherlands.

Sabrina van Heukelum (S)

Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University, the Netherlands.

Floriana Mogavero (F)

Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University, the Netherlands.

Antonio Lobo (A)

Instituto de Investigación Sanitaria de Aragón (IIS Aragón), CIBERSAM, Instituto de Salud Carlos III, Universidad de Zaragoza, Spain.

Francisco Javier Olivera (FJ)

Instituto de Investigación Sanitaria de Aragón (IIS Aragón), CIBERSAM, Instituto de Salud Carlos III, Universidad de Zaragoza, Spain.

Elena Lobo (E)

Instituto de Investigación Sanitaria de Aragón (IIS Aragón), CIBERSAM, Instituto de Salud Carlos III, Universidad de Zaragoza, Spain.

Mar Posadas (M)

Instituto de Investigación Sanitaria de Aragón (IIS Aragón), CIBERSAM, Instituto de Salud Carlos III, Universidad de Zaragoza, Spain.

Juergen Dukart (J)

F. Hoffmann-La Roche, Pharma Research Early Development, Roche Innovation Centre Basel, Basel, Switzerland.

Rouba Kozak (R)

Neuroscience Research Unit, Global Research & Development, Pfizer Inc., UK.

Estibaliz Arce (E)

Neuroscience Research Unit, Global Research & Development, Pfizer Inc., UK.

Arfan Ikram (A)

Department of Epidemiology, Erasmus University Medical Center Rotterdam, the Netherlands.

Jacob Vorstman (J)

Kinder-en jeugdpsychiater & onderzoeker, Divisie Hersenen, Psychiatrie, Universitair Medisch Centrum Utrecht, the Netherlands.

Amy Bilderbeck (A)

P1vital Ltd., UK.

Ilja Saris (I)

VU University Medical Center, Department of Psychiatry, Amsterdam, the Netherlands.

Martien J Kas (MJ)

Groningen Institute for Evolutionary Life Sciences, University of Groningen, the Netherlands.

Alessandro Serretti (A)

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Italy.

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Classifications MeSH

questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Affect › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Comportement et mécanismes comportementaux › Relations interpersonnelles › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Troubles mentaux › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Système nerveux › Voies nerveuses › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Disciplines et activités comportementales › Psychologie des schizophrènes › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Sciences sociales › Sociologie › Facteurs sociologiques › Isolement social › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception sociale › Social brain, social dysfunction and social withdrawal.
questionsmedicales.fr › Phénomènes psychologiques › Théorie psychologique › Théorie de l'esprit › Social brain, social dysfunction and social withdrawal.