Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis.
idiopathic pulmonary fibrosis
interstitial fibrosis
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
04
04
2018
revised:
24
08
2018
accepted:
27
08
2018
pubmed:
24
9
2018
medline:
16
5
2019
entrez:
24
9
2018
Statut:
ppublish
Résumé
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology which leads rapidly to death. As diagnosis of IPF is complex, we aimed to characterise microRNA (miRNA) content of exosomes from sputum of patients with IPF. Using miRNA quantitative PCR array, we found a substantial dysregulation of sputum exosomal miRNA levels between patients with IPF and healthy subjects and identified a unique signature of three miRNAs. Interestingly, we found a negative correlation between miR-142-3p and diffusing capacity of the lungs for carbon monoxide/alveolar volume. This is the first characterisation of miRNA content of sputum-derived exosomes in IPF that identified promising biomarkers for diagnosis and disease severity.
Identifiants
pubmed: 30244194
pii: thoraxjnl-2018-211897
doi: 10.1136/thoraxjnl-2018-211897
pmc: PMC6467246
doi:
Substances chimiques
Biomarkers
0
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
309-312Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
PLoS One. 2012;7(3):e30679
pubmed: 22427800
J Allergy Clin Immunol. 2017 Nov;140(5):1459-1461.e2
pubmed: 28629752
Am J Respir Crit Care Med. 2010 Jul 15;182(2):220-9
pubmed: 20395557
Trends Endocrinol Metab. 2017 Mar;28(3):237-246
pubmed: 27989505
Development. 2014 Mar;141(6):1272-81
pubmed: 24553287
Eur Respir J. 2003 Oct;22(4):578-83
pubmed: 14582906
Eur Respir J. 2011 Apr;37(4):743-6
pubmed: 21454891
Lung. 2017 Jun;195(3):273-280
pubmed: 28353114
PLoS One. 2017 Feb 8;12(2):e0171344
pubmed: 28178340