Effectiveness of dorsal root ganglion stimulation and dorsal column spinal cord stimulation in a model of experimental painful diabetic polyneuropathy.
Animals
Diabetes Mellitus, Experimental
/ physiopathology
Diabetic Neuropathies
/ physiopathology
Disease Models, Animal
Electric Stimulation Therapy
/ instrumentation
Female
Ganglia, Spinal
/ physiopathology
Pain
/ physiopathology
Pain Management
/ methods
Rats, Sprague-Dawley
Spinal Cord
/ physiopathology
animal model
dorsal root ganglion stimulation
neuromodulation
painful diabetic polyneuropathy
spinal cord stimulation
Journal
CNS neuroscience & therapeutics
ISSN: 1755-5949
Titre abrégé: CNS Neurosci Ther
Pays: England
ID NLM: 101473265
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
15
05
2018
revised:
31
07
2018
accepted:
21
08
2018
pubmed:
25
9
2018
medline:
23
6
2020
entrez:
25
9
2018
Statut:
ppublish
Résumé
Conventional dorsal root ganglion stimulation (DRGS) is known to achieve better pain-paresthesia overlap of difficult-to-reach areas like the feet compared to dorsal column spinal cord stimulation (SCS). As in painful diabetic polyneuropathy (PDPN) pain is mostly present in the feet, we hypothesized that DRGS is more effective in relieving pain in PDPN when compared to SCS. Diabetes was induced in female Sprague-Dawley rats with an intraperitoneal injection of 65 mg/kg of streptozotocin (STZ; n = 48). Rats with a significant decrease in mechanical paw withdrawal response to von Frey filaments 4 weeks after injection were implanted with DRGS electrodes (n = 18). Rats were assigned to DRGS (n = 11) or sham-DRGS (n = 7). Mechanical paw withdrawal thresholds (WT, measured in grams) in response to DRGS (50 Hz, 0.18 ± 0.05 mA) were assessed with von Frey testing. The results of the experiments on these animals were compared to the results of a previous study using exactly the same model on PDPN animals selected for SCS (n = 8) (40-50 Hz, 0.19 ± 0.01 mA) and sham-SCS (n = 3). In the SCS group, the log We conclude that conventional DRGS is as effective as SCS in reduction of PDPN-associated mechanical hypersensitivity in STZ-induced diabetic rats. The wash-in effect of DRGS and SCS was similar, but DRGS showed a faster washout course. Long-term efficacy should be studied in future animal research.
Identifiants
pubmed: 30246327
doi: 10.1111/cns.13065
pmc: PMC6488890
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
367-374Informations de copyright
© 2018 John Wiley & Sons Ltd.
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