Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms.
Bronchial carcinoid tumours
NET
Neuroendocrine neoplasms
Pulmonary carcinoids
Journal
Neuroendocrinology
ISSN: 1423-0194
Titre abrégé: Neuroendocrinology
Pays: Switzerland
ID NLM: 0035665
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
07
2018
accepted:
16
09
2018
pubmed:
25
9
2018
medline:
18
12
2019
entrez:
25
9
2018
Statut:
ppublish
Résumé
Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- and intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.
Identifiants
pubmed: 30248673
pii: 000493980
doi: 10.1159/000493980
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-17Investigateurs
Detlef Bartsch
(D)
Rudolf Arnold
(R)
Eric Baudin
(E)
Lisa Bodei
(L)
Ivan Borbath
(I)
Jaume Capdevila
(J)
Martyn Caplin
(M)
Jie Chen
(J)
Frederico Costa
(F)
Anne Couvelard
(A)
Jaroslaw Ćwikła
(J)
Philippa Davies
(P)
Herder de
(H)
Massimo Falconi
(M)
Jenny Falkerby
(J)
Nicola Fazio
(N)
Diego Ferone
(D)
Andrea Frilling
(A)
Rocio Garcia-Carbonero
(R)
Simona Glasberg
(S)
Vera Gorbunova
(V)
Ashley Grossman
(A)
Dieter Hörsch
(D)
Robert Jensen
(R)
Gregory Kaltsas
(G)
Günter Klöppel
(G)
Ulrich Knigge
(U)
Beata Kos-Kudła
(B)
Guenter Krejs
(G)
Eric Krenning
(E)
Matthew Kulke
(M)
Steven Lamberts
(S)
van Nieveen
(V)
Juan O'Connor
(J)
Dermot O'Toole
(D)
Ulrich-Frank Pape
(UF)
Stefano Partelli
(S)
Marianne Pavel
(M)
Marc Peeters
(M)
John Ramage
(J)
Nicholas Reed
(N)
Guido Rindi
(G)
Anja Rinke
(A)
Philippe Ruszniewski
(P)
Halfdan Sorbye
(H)
Anders Sundin
(A)
Jean-Yves Scoazec
(JY)
Babs Taal
(B)
Janson Tiensuu
(J)
Christos Toumpanakis
(C)
Juan Valle
(J)
Marie-Pierre Vullierme
(MP)
Staffan Welin
(S)
Bertram Wiedenmann
(B)
Informations de copyright
© 2018 S. Karger AG, Basel.