Higher-energy collision-induced dissociation for the quantification by liquid chromatography/tandem ion trap mass spectrometry of nitric oxide metabolites coming from S-nitroso-glutathione in an in vitro model of the intestinal barrier.
Journal
Rapid communications in mass spectrometry : RCM
ISSN: 1097-0231
Titre abrégé: Rapid Commun Mass Spectrom
Pays: England
ID NLM: 8802365
Informations de publication
Date de publication:
15 Jan 2019
15 Jan 2019
Historique:
received:
03
05
2018
revised:
14
09
2018
accepted:
14
09
2018
pubmed:
25
9
2018
medline:
5
1
2019
entrez:
25
9
2018
Statut:
ppublish
Résumé
The potency of S-nitrosoglutathione (GSNO) as a nitric oxide (NO) donor to treat cardiovascular diseases (CVDs) has been highlighted in numerous studies. In order to study its bioavailability after oral administration, which represents the most convenient route for the chronic treatment of CVDs, it is essential to develop an analytical method permitting (i) the simultaneous measurement of GSNO metabolites, i.e. nitrite, S-nitrosothiols (RSNOs) and nitrate and (ii) to distinguish them from other sources (endogenous synthesis and diet). Exogenous GSNO was labeled with A LC/ITMS/MS method based on an original transition (m/z 171 to 156) for sodium A quantitative LC/ITMS/MS method using HCD was developed for the first time to selectively monitor GS
Substances chimiques
Nitrites
0
2,3-diaminonaphthalene
2BNZ6BRS87
Nitric Oxide
31C4KY9ESH
S-Nitrosoglutathione
57564-91-7
2-Naphthylamine
CKR7XL41N4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-11Subventions
Organisme : China Scholarship Council
ID : 201506270166
Informations de copyright
© 2018 John Wiley & Sons, Ltd.