Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney.

Animals Benzydamine / metabolism Kidney / enzymology Macaca fascicularis / genetics Oxygenases / genetics
drug-metabolizing enzyme activity flavin-containing monooxygenase immunoblotting sex difference

Journal

Journal of medical primatology
ISSN: 1600-0684
Titre abrégé: J Med Primatol
Pays: Denmark
ID NLM: 0320626

Informations de publication

Date de publication:
02 2019
Historique:
received: 03 04 2018
accepted: 28 08 2018
pubmed: 27 9 2018
medline: 16 4 2020
entrez: 26 9 2018
Statut: ppublish

Résumé

Flavin-containing monooxygenase 1 (FMO1) largely remains to be characterized in cynomolgus macaque kidney. Immunoblotting showed expression of cynomolgus FMO1 in kidneys where activities of FMO1 (benzydamine N-oxygenation) were detected. No sex differences were observed in their contents or activities. These results suggest the functional role of cynomolgus FMO1 in kidney.

Identifiants

DOI: 10.1111/jmp.12385 PMID: 30252147
pubmed: 30252147
doi: 10.1111/jmp.12385
doi:

Substances chimiques

Benzydamine 4O21U048EF
Oxygenases EC 1.13.-
dimethylaniline monooxygenase (N-oxide forming) EC 1.14.13.8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

51-53

Informations de copyright

© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Auteurs

Yasuhiro Uno (Y)

Shin Nippon Biomedical Laboratories, Ltd., Kainan, Japan.

Makiko Shimizu (M)

Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.

Hiromi Yoda (H)

Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.

Hiroshi Yamazaki (H)

Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
ORCID: 0000-0002-1068-4261

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Expression and metabolic activity of...
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questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Expression and metabolic activity of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca fascicularis › Expression and metabolic activity of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Expression and metabolic activity of...