Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.
Animals
Autophagy
Doxorubicin
/ toxicity
Erythroblasts
/ enzymology
Erythropoiesis
/ drug effects
Female
Janus Kinase 2
/ metabolism
Mice
Mice, Knockout
NF-E2-Related Factor 2
/ metabolism
Oxidation-Reduction
Oxidative Stress
/ physiology
Phenylhydrazines
/ toxicity
Phosphorylation
Protein Processing, Post-Translational
Proto-Oncogene Proteins c-fyn
/ deficiency
Reactive Oxygen Species
Receptors, Erythropoietin
/ metabolism
STAT5 Transcription Factor
/ metabolism
Signal Transduction
Sirolimus
/ pharmacology
TOR Serine-Threonine Kinases
/ metabolism
Journal
American journal of hematology
ISSN: 1096-8652
Titre abrégé: Am J Hematol
Pays: United States
ID NLM: 7610369
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
14
09
2018
revised:
17
09
2018
accepted:
19
09
2018
pubmed:
27
9
2018
medline:
13
11
2019
entrez:
26
9
2018
Statut:
ppublish
Résumé
The signaling cascade induced by the interaction of erythropoietin (EPO) with its receptor (EPO-R) is a key event of erythropoiesis. We present here data indicating that Fyn, a Src-family-kinase, participates in the EPO signaling-pathway, since Fyn
Identifiants
pubmed: 30252956
doi: 10.1002/ajh.25295
pmc: PMC7213426
mid: NIHMS1062670
doi:
Substances chimiques
NF-E2-Related Factor 2
0
Nfe2l2 protein, mouse
0
Phenylhydrazines
0
Reactive Oxygen Species
0
Receptors, Erythropoietin
0
STAT5 Transcription Factor
0
phenylhydrazine
064F424C9K
Doxorubicin
80168379AG
mTOR protein, mouse
EC 2.7.1.1
Fyn protein, mouse
EC 2.7.10.2
Jak2 protein, mouse
EC 2.7.10.2
Janus Kinase 2
EC 2.7.10.2
Proto-Oncogene Proteins c-fyn
EC 2.7.10.2
TOR Serine-Threonine Kinases
EC 2.7.11.1
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-20Subventions
Organisme : NCI NIH HHS
ID : R01 CA205975
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136255
Pays : United States
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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