Functional slit lamp biomicroscopy metrics correlate with cardiovascular risk.
Aged
Blood Flow Velocity
/ physiology
Cardiovascular Diseases
/ diagnosis
Conjunctiva
/ blood supply
Cross-Sectional Studies
Female
Humans
Image Processing, Computer-Assisted
Incidence
Male
Microcirculation
/ physiology
Microvessels
/ diagnostic imaging
Middle Aged
Predictive Value of Tests
Prevalence
Prospective Studies
Risk Assessment
/ methods
Risk Factors
Slit Lamp Microscopy
/ methods
United States
/ epidemiology
Cardiovascular risk estimation
Conjunctival blood vessels
Functional slit lamp imaging
Journal
The ocular surface
ISSN: 1937-5913
Titre abrégé: Ocul Surf
Pays: United States
ID NLM: 101156063
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
29
06
2018
revised:
31
08
2018
accepted:
12
09
2018
pubmed:
27
9
2018
medline:
2
6
2020
entrez:
26
9
2018
Statut:
ppublish
Résumé
Our aim was to correlate cardiovascular risk factor estimation with bulbar conjunctival blood flow metrics as measured through Functional Slit Lamp Biomicroscopy (FSLB). Cross-sectional study of individuals with otherwise healthy eyelid and corneal anatomy recruited from the Miami Veterans Affairs (VA) Healthcare System eye clinic. We measured conjunctival microvascular hemodynamics by mounting a camera on a slit lamp and cardiovascular risk using the Framingham risk score. Our main outcome measures were correlations between conjunctival vessel parameters (axial and cross-sectional blood flow velocity, blood flow rate) and Framingham score. We included 84 patients who underwent FSLB. The mean age was 60 years, the majority were male (88%) and approximately half the patients were black (54%). Mean vessel diameter was similar between all Framingham score categories. Axial and cross-sectional blood flow velocities and blood flow rate were lower in individuals with higher Framingham risk score. Specifically, mean cross-sectional blood flow velocity in individuals with a low Framingham risk score was 0.37 ± 0.0.9 mm/s, with an intermediate score was 0.30 ± 0.09 mm/s, and with a high score was 0.29 ± 0.10 mm/s, p = 0.04. Mean blood flow rate in individuals with a low Framingham risk score was 133.4 ± 59.6 pl/s, with an intermediate score was 123.6 ± 39.3 pl/s, and with a high score was 121.9 ± 52.6 pl/s, p = 0.04. The beta coefficient of the blood flow rate for change in Framingham score was -0.73; 95% CI-1.34-0.13, p = 0.02, adjusted for race. FSLB correlates with cardiovascular risk estimation. Future studies should evaluate if FSLB can predict cardiovascular outcomes.
Identifiants
pubmed: 30253248
pii: S1542-0124(18)30203-9
doi: 10.1016/j.jtos.2018.09.002
pmc: PMC6340746
mid: NIHMS1508720
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
64-69Subventions
Organisme : BLRD VA
ID : I01 BX004893
Pays : United States
Organisme : CSRD VA
ID : I01 CX001089
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY014801
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026174
Pays : United States
Informations de copyright
Copyright © 2018. Published by Elsevier Inc.
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