Amino acids and amino acid sensing: implication for aging and diseases.
Aging and age-related diseases
Amino acid availability
Amino acid sensing
Amino acid supplementation
Amino acid transporters
mTORC1 pathway
Journal
Biogerontology
ISSN: 1573-6768
Titre abrégé: Biogerontology
Pays: Netherlands
ID NLM: 100930043
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
09
06
2018
accepted:
16
09
2018
pubmed:
27
9
2018
medline:
8
6
2019
entrez:
27
9
2018
Statut:
ppublish
Résumé
Biogerontological research indicates nutrition as one of the major determinants of healthy aging, due to the role of nutrients in maintaining the dynamic-homeostasis of the organism. In this frame, the importance of proteins and constitutive amino acids (AAs), and in particular of functional AAs is emerging. The ability to sense and respond to changes in AAs availability is mediated by a complex network of dynamic players, crucial for an efficient regulation of their downstream effects. Here, we reviewed the current knowledge about the involvement of AA sensing mechanisms in aging and age-related diseases, focusing our attention on mTORC1 and AA transporters. In this context it is of note that alterations in AA sensors have been reported to be directly implicated in age-related phenotypes, suggesting that their modulation can represent a possible strategy for modulating (and possibly delaying) aging decline. Furthermore, these alterations may influence the effects of AA supplementation, by influencing the individual answer to AA availability. On the whole, evidences support the hypothesis that the efficiency of components of AA sensing network may have important implications for therapy, and their knowledge may be crucial for programming AA supplementation for contrasting age-related phenotypes, opening new opportunities for therapeutic interventions aimed to promote human health span.
Identifiants
pubmed: 30255223
doi: 10.1007/s10522-018-9770-8
pii: 10.1007/s10522-018-9770-8
doi:
Substances chimiques
Amino Acid Transport Systems
0
Amino Acids
0
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-31Références
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