Management of hepatitis C virus infection in patients with chronic kidney disease: position statement of the joint committee of Italian association for the study of the liver (AISF), Italian society of internal medicine (SIMI), Italian society of infectious and tropical disease (SIMIT) and Italian society of nephrology (SIN).

Chronic kidney disease Direct-acting antiviral agents HCV in renal transplantation HCV infection

Journal

Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307

Informations de publication

Date de publication:
Feb 2019
Historique:
received: 28 03 2018
accepted: 09 08 2018
pubmed: 27 9 2018
medline: 17 4 2019
entrez: 27 9 2018
Statut: ppublish

Résumé

Hepatitis C virus (HCV) infection is now considered a systemic disease due to the occurrence of extra-hepatic manifestations. Among these, the renal involvement is frequent. HCV infection, in fact, is strongly associated with proteinuria and chronic kidney disease (CKD) and negatively affects the prognosis of renal patients. In the last few years, availability of more specific and effective drugs against HCV has dramatically changed the clinical course of this disease. These drugs may provide further advantages in the CKD population as a whole by reducing progression of renal disease, mortality rate and by increasing the survival of graft in renal transplant recipients. The strict pathogenetic and prognostic link between HCV infection and CKD requires an ongoing relationship among the healthcare professionals involved in the treatment of both HCV infection and CKD. Therefore, Scientific Societies involved in the care of this high-risk population in Italy have organized a joint expert panel. The aim of the panel is to produce a position statement that can be used in daily clinical practice for the management of HCV infected patients across the whole spectrum of renal disease, from the conservative phase to renal replacement treatments (dialysis and transplantation). Sharing specific evidence-based expertise of different professional healthcare is the first step to obtain a common ground of knowledge on which to instate a model for multidisciplinary management of this high-risk population. Statements cover seven areas including epidemiology of CKD, HCV-induced glomerular damage, HCV-related renal risk, staging of liver disease in patients with CKD, prevention of transmission of HCV in hemodialysis units, treatment of HCV infection and management of HCV in kidney transplantation.

Identifiants

pubmed: 30255389
doi: 10.1007/s15010-018-1209-2
pii: 10.1007/s15010-018-1209-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

141-168

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Auteurs

Roberto Minutolo (R)

Division of Nephrology, Department of Scienze Mediche, Chirurgiche, Neurologiche, Metaboliche e dell'Invecchiamento, University of Campania "Luigi Vanvitelli", Via M. Longo 50, 80138, Naples, Italy. roberto.minutolo@unicampania.it.

Alessio Aghemo (A)

Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Division of Internal Medicine and Hepatology, Humanitas Clinical and Research Center, Milan, Italy.

Antonio Chirianni (A)

Third Department of Infectious Diseases Azienda Ospedaliera Ospedali dei Colli, Naples, Italy.

Fabrizio Fabrizi (F)

Division of Nephrology, Maggiore Hospital and IRCCS Foundation, Milan, Italy.

Loreto Gesualdo (L)

Division of Nephrology, Azienda Ospedaliero-Universitaria Policlinico di Bari, Bari, Italy.

Edoardo G Giannini (EG)

Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy.

Paolo Maggi (P)

Infectious Disease Clinic, University of Bari, Bari, Italy.

Vincenzo Montinaro (V)

Division of Nephrology, Azienda Ospedaliero-Universitaria Policlinico di Bari, Bari, Italy.

Ernesto Paoletti (E)

Nephrology, Dialysis, and Transplantation, University of Genoa and Policlinico San Martino, Genoa, Italy.

Marcello Persico (M)

Internal Medicine and Hepatology Unit, AOU San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.

Francesco Perticone (F)

Department of Medical and Surgical Sciences, University Magna Græcia, Catanzaro, Italy.

Salvatore Petta (S)

Gastroenterology and Hepatology Unit, Di.Bi.M.I.S., University of Palermo, Palermo, Italy.

Massimo Puoti (M)

Division of Infectious Diseases, Niguarda Cà Granda Hospital, Milan, Italy.

Giovanni Raimondo (G)

Department of Medicina Clinica e Sperimentale, University of Messina, Messina, Italy.

Maria Rendina (M)

Department of Emergency and Organ Transplantation, Section of Gastroenterology, University Hospital, Bari, Italy.

Anna Linda Zignego (AL)

Department of Experimental and Clinical Medicine, Interdepartmental Hepatology Center MaSVE, University of Florence, Florence, Italy.

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