[Mimetics of systemic sclerosis].
Imitatoren der systemischen Sklerose.
Morphea
Nephrogenic systemic fibrosis
Scleroderma
Scleromyxedema
Skin fibrosis
Journal
Zeitschrift fur Rheumatologie
ISSN: 1435-1250
Titre abrégé: Z Rheumatol
Pays: Germany
ID NLM: 0414162
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
pubmed:
27
9
2018
medline:
3
10
2019
entrez:
27
9
2018
Statut:
ppublish
Résumé
Systemic sclerosis (SSc) is characterized by heterogeneous clinical symptoms. Peripheral skin fibrosis can be a common symptom. Nevertheless, a variety of diseases with different etiologies are associated with a thickening of the skin and make the initial diagnosis of systemic sclerosis more difficult. The different disease entities that can lead to dermal fibrosis should be differentiated. An earlier diagnosis of SSc would therefore be facilitated. A literature search was carried out for clinical pictures that can be associated with skin fibrosis. The clinical picture, the etiology and the treatment of the individual diseases are described. Diseases that can mimic the cutaneous symptoms of SSc include morphea, scleroderma, diabetic cheirarthritis, scleromyxedema, nephrogenic systemic fibrosis and eosinophilic fasciitis. The characteristic pronounced skin involvement, an accompanying Raynaud's phenomenon, capillary microscopy, histopathology and antinuclear antibodies help to enable a differentiation of SSc from its mimics. An early differential diagnostic distinction between SSc and other sclerosing diseases is important due to SSc-associated and potentially life-threatening systemic organ involvement. If a diagnosis of SSc has been made, a critical and organ-specific evaluation with respect to pulmonary, gastrointestinal, renal and cardiac involvement is mandatory and should be repeated at regular intervals.
Sections du résumé
BACKGROUND
BACKGROUND
Systemic sclerosis (SSc) is characterized by heterogeneous clinical symptoms. Peripheral skin fibrosis can be a common symptom. Nevertheless, a variety of diseases with different etiologies are associated with a thickening of the skin and make the initial diagnosis of systemic sclerosis more difficult.
OBJECTIVE
OBJECTIVE
The different disease entities that can lead to dermal fibrosis should be differentiated. An earlier diagnosis of SSc would therefore be facilitated.
METHODS
METHODS
A literature search was carried out for clinical pictures that can be associated with skin fibrosis. The clinical picture, the etiology and the treatment of the individual diseases are described.
RESULTS
RESULTS
Diseases that can mimic the cutaneous symptoms of SSc include morphea, scleroderma, diabetic cheirarthritis, scleromyxedema, nephrogenic systemic fibrosis and eosinophilic fasciitis. The characteristic pronounced skin involvement, an accompanying Raynaud's phenomenon, capillary microscopy, histopathology and antinuclear antibodies help to enable a differentiation of SSc from its mimics.
CONCLUSION
CONCLUSIONS
An early differential diagnostic distinction between SSc and other sclerosing diseases is important due to SSc-associated and potentially life-threatening systemic organ involvement. If a diagnosis of SSc has been made, a critical and organ-specific evaluation with respect to pulmonary, gastrointestinal, renal and cardiac involvement is mandatory and should be repeated at regular intervals.
Identifiants
pubmed: 30255410
doi: 10.1007/s00393-018-0538-y
pii: 10.1007/s00393-018-0538-y
doi:
Types de publication
Journal Article
Review
Langues
ger
Sous-ensembles de citation
IM
Pagination
14-23Références
Arch Klin Exp Dermatol. 1954;199(1):71-91
pubmed: 13229312
AJR Am J Roentgenol. 2005 Jan;184(1):169-74
pubmed: 15615969
Semin Arthritis Rheum. 2006 Jun;35(6):355-9
pubmed: 16765712
J Am Soc Nephrol. 2006 Sep;17(9):2359-62
pubmed: 16885403
Dermatology. 2006;213(2):93-101
pubmed: 16902285
Radiology. 2007 Mar;242(3):647-9
pubmed: 17213364
Arthritis Rheum. 2008 Aug;58(8):2543-8
pubmed: 18668587
Clin Rheumatol. 2009 Jun;28(6):729-32
pubmed: 19224125
Arch Dermatol. 2009 May;145(5):545-50
pubmed: 19451498
Radiol Clin North Am. 2009 Sep;47(5):833-40, vi
pubmed: 19744598
Rheumatology (Oxford). 2012 Mar;51(3):557-61
pubmed: 22120602
Curr Rheumatol Rep. 2012 Feb;14(1):39-46
pubmed: 22131103
Eur J Haematol. 2012 May;88(5):450-4
pubmed: 22404151
Arthritis Care Res (Hoboken). 2012 Aug;64(8):1175-85
pubmed: 22505322
Arch Dermatol. 1990 May;126(5):613-7
pubmed: 2334180
J Am Acad Dermatol. 2013 Jul;69(1):66-72
pubmed: 23453242
Curr Opin Rheumatol. 2013 Nov;25(6):692-9
pubmed: 24061074
Arthritis Rheum. 2013 Nov;65(11):2737-47
pubmed: 24122180
Am J Dermatopathol. 2014 Jun;36(6):449-64
pubmed: 24423930
Ann Hematol. 2014 Nov;93(11):1927-8
pubmed: 24676971
JAMA Dermatol. 2014 Jul;150(7):788-9
pubmed: 24847975
Curr Opin Rheumatol. 2014 Nov;26(6):658-62
pubmed: 25215418
Curr Treatm Opt Rheumatol. 2016 Mar;2(1):69-84
pubmed: 28473954
J Eur Acad Dermatol Venereol. 2017 Oct;31(10):1581-1594
pubmed: 28786499
J Eur Acad Dermatol Venereol. 2017 Sep;31(9):1401-1424
pubmed: 28792092
Semin Arthritis Rheum. 1988 May;17(4):221-31
pubmed: 3232080
Am J Dermatopathol. 1996 Oct;18(5):465-73
pubmed: 8902092
J Dermatol. 1998 Feb;25(2):103-7
pubmed: 9563277
Medicina (B Aires). 1998;58(5 Pt 1):501-3
pubmed: 9922484