Four-miRNA Signature to Identify Asbestos-Related Lung Malignancies.
Aged
Asbestos
/ toxicity
Biomarkers, Tumor
/ blood
Carcinogens
/ toxicity
Carcinoma, Non-Small-Cell Lung
/ chemically induced
Female
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms
/ chemically induced
Male
Mesothelioma
/ chemically induced
Mesothelioma, Malignant
MicroRNAs
/ blood
Middle Aged
Sensitivity and Specificity
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
24
04
2018
revised:
29
06
2018
accepted:
17
09
2018
pubmed:
28
9
2018
medline:
12
2
2020
entrez:
28
9
2018
Statut:
ppublish
Résumé
Altered miRNA expression is an early event upon exposure to occupational/environmental carcinogens; thus, identification of a novel asbestos-related profile of miRNAs able to distinguish asbestos-induced cancer from cancer with different etiology can be useful for diagnosis. We therefore performed a study to identify miRNAs associated with asbestos-induced malignancies. Four groups of patients were included in the study, including patients with asbestos-related (NSCLC Four serum miRNAs, that is miR-126, miR-205, miR-222, and miR-520g, were found to be implicated in asbestos-related malignant diseases. Notably, increased expression of miR-126 and miR-222 were found in asbestos-exposed subjects, and both miRNAs are involved in major pathways linked to cancer development. Epigenetic changes and cancer-stroma cross-talk could induce repression of miR-126 to facilitate tumor formation, angiogenesis, and invasion. This study indicates that miRNAs are potentially involved in asbestos-related malignancies, and their expression outlines mechanism(s) whereby miRNAs may be involved in an asbestos-induced pathogenesis. The discovery of a miRNA panel for asbestos-related malignancies would impact on occupational compensation and may be utilized for screening asbestos-exposed populations.
Sections du résumé
BACKGROUND
Altered miRNA expression is an early event upon exposure to occupational/environmental carcinogens; thus, identification of a novel asbestos-related profile of miRNAs able to distinguish asbestos-induced cancer from cancer with different etiology can be useful for diagnosis. We therefore performed a study to identify miRNAs associated with asbestos-induced malignancies.
METHODS
Four groups of patients were included in the study, including patients with asbestos-related (NSCLC
RESULTS
Four serum miRNAs, that is miR-126, miR-205, miR-222, and miR-520g, were found to be implicated in asbestos-related malignant diseases. Notably, increased expression of miR-126 and miR-222 were found in asbestos-exposed subjects, and both miRNAs are involved in major pathways linked to cancer development. Epigenetic changes and cancer-stroma cross-talk could induce repression of miR-126 to facilitate tumor formation, angiogenesis, and invasion.
CONCLUSIONS
This study indicates that miRNAs are potentially involved in asbestos-related malignancies, and their expression outlines mechanism(s) whereby miRNAs may be involved in an asbestos-induced pathogenesis.
IMPACT
The discovery of a miRNA panel for asbestos-related malignancies would impact on occupational compensation and may be utilized for screening asbestos-exposed populations.
Identifiants
pubmed: 30257964
pii: 1055-9965.EPI-18-0453
doi: 10.1158/1055-9965.EPI-18-0453
doi:
Substances chimiques
Biomarkers, Tumor
0
Carcinogens
0
MIRN126 microRNA, human
0
MIRN205 microRNA, human
0
MIRN222 microRNA, human
0
MicroRNAs
0
Asbestos
1332-21-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-126Informations de copyright
©2018 American Association for Cancer Research.